[PAGID] CVID with absent IgG

[K. Scott Baker]

We recently saw a 16 yr old female admitted to the general peds service with
pneumonia several months ago with the same immunoglobulin picture (IGG
around 40).  No significant prior history outside of the few months prior to
admission. Rest of workup has been uninformative.
-- 
K. Scott Baker, MD, MS
Associate Professor of Pediatrics
University of Minnesota


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> From: "Saxon, Andy M.D." <ASaxon at mednet.ucla.edu>
> Reply-To: <pagid at clinimmsoc.org>
> Date: Mon, 5 Dec 2005 08:35:22 -0800
> To: "'pagid at clinimmsoc.org'" <pagid at clinimmsoc.org>
> Cc: "Stacy Lee (E-mail)" <slee52 at ucla.edu>
> Subject: RE: [PAGID] CVID with absent IgG
> 
> Thanks. Nice to know as we didn't know if this represented anything out of
> the regular spectrum. I guess not.
> 
> Andy
> 
> -----Original Message-----
> From: Charlotte Cunningham-Rundles
> [mailto:charlotte.cunningham-rundles at mssm.edu]
> Sent: Friday, December 02, 2005 2:32 PM
> To: pagid at clinimmsoc.org
> Subject: Re: [PAGID] CVID with absent IgG
> 
> 
> we have a group of these ---- it is always interesting how little Ig
> you can find in these adults
> 
>> A colleague of mine recently saw a 58 yo man with a history of 10+ years of
>> recurrent pneumonia and one episode of bacterial sepsis. His QIG was IgA <
> 7
>> mg/dL (nl 80-400), IgG <8 mg/dl (nl 690-1660). IgE ,0.1 IU/mL. IgM not done
>> but "decreased" on IEP.  C3, C4, T and B cells % and # normal but CD4 28%
>> with absolute 294 (normal 355-1426.)  Albumin 3.1 with nl 3.3-4.7
>> 
>> I have seen a fair # of CVID in my time but I don't recall seeing one with
>> an IgG this low...  What is your experience.
>> 
>> Andy Saxon, UCLA
> 
> 
> -- 
> 
> 
> Charlotte Cunningham-Rundles MD PhD
> Professor of Medicine, Pediatrics  and Immunobiology
> Mount Sinai School of Medicine
> 1425 Madison Ave, New York 10029
> phone 212 659 9268
> fax  212 987 5593
> Email:  charlotte.cunningham-rundles at mssm.edu
>