[PAGID] IFN-gamma

[Christine Seroogy]

Hi,

I would like to hear people's opinions about the use of IFN-g in the  
setting of acute infection in CGD patients.  We have a newly  
diagnosed 2.5 year boy who presented with aspergillus pneumonia.  His  
DHR looks like gp91 but Mom's DHR was completely normal and molecular  
diagnosis is pending.  He clinically has been very stable despite a  
terrible looking lung CT (one month into therapy).  We have confirmed  
aspergillus and now have sensitivities and will be treating him with  
voriconazole and caspofungin IV.

He has never been on IFN-g and the opinions I have received thus far  
are mixed.

Thanks for any input.  Chris