[PAGID] PID related tumors

[Saxon, Andy M.D.]

Thanks.
 
That I interpret as primarily related to the DNA repair issues in AT and a
lymphoproliferative disorder.
 
I'm wondering if any of the potentially virally related tumors (papilloma -
cervix) or others or those purported to have an immune regulation component,
e.g. melanoma, renal cells are increased in PID.  ANYONE???
 
Andy

-----Original Message-----
From: pagid-bounces at clinimmsoc.org [mailto:pagid-bounces at clinimmsoc.org]On
Behalf Of Sergio Rosenzweig
Sent: Sunday, June 04, 2006 12:02 PM
To: pagid at clinimmsoc.org
Subject: Re: [PAGID] PID related tumors


Dear Andy,
In the last 6 months we have had a "little outbreake" of tumors in our
cohort of near 500 PID ped pts.
-1 hepatocellular carcinoma in a teen A-T female pt (Hep B and C neg)
-1 Hodgkin lymphoma in a teen A-T female pt
-1 EBV (+) B cell lymphoma in 2 yo male cartilage-hair hypoplasia pt
Regarding the other tumors/localizations, as far as I remember, we still
havent seen any.
Regards,
Sergio
PS Hope you are enjoying FOCIS
 
Sergio D. Rosenzweig, MD
Servicio de Inmunologia
Hospital Nacional de Pediatria J. P. Garrahan
Buenos Aires, Argentina
srosenzweig at garrahan.gov.ar <mailto:srosenzweig at garrahan.gov.ar> 

"Saxon, Andy M.D." <ASaxon at mednet.ucla.edu> wrote:

What is the feeling out there as to malignancies, other than hematopoetic
cancers (e.g. lymphoma, leukemias) and thymoma that are clearly increased in
PID; 

I'd love to get the impute from a lot of you on this

? Skin Basal Cell
Melanoma
Squamous Cell

?GI Gastric (assoc with atrophic gastritis in CVID)


? Others
Cervix ?
Breast?
Testicular?
Kidney
Prostate?
Colon?

Thanks 

Andy Saxon, MD
UCLA


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