[PAGID] diabetes and hypogammaglobulinemia

[Jung, Lawrence]

I  have a 15 y.o. previously healthy Caucasian male patient who was
diagnosed to juvenile diabetes last July.  While his diabetes was
controlled he started to develop episodes of low grade fever, fatigue
and searches for infections were never positive.  

 

IgG was 422   IgA 23 and IgM 26.  [ all low for our lab]

IgG1 - 245, IG2 - 30, IgG3 - 22 and IgG4 - 2.   

CD3- 1048, CD4 - 585, CD8- 407, CD19 - 534.  

 

He makes normal levels of antibodies to Diphtheria, tetanus and various
pneumococcal serotypes.  Neg CMV serology.  EBV VCA IgG + IgM - EBNA +
EA -.

 

Any suggestions as to the etiology of the "low" IgG's and how may it be
related to the diabetes?  Is he at risk for developing other autoimmune
diseases?   Parents ask whether IVIg should be given to prevent
development of the latter.

 

Thanks for your comments.

 

Larry Jung

Omaha, NE  

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