[PAGID] post gamma globulin psychiatric disorder

[Sergio Rosenzweig]

Richard,
Was the patient tested for enterovirus encephalitis?

Sergio

Sergio D. Rosenzweig, MD, PhD
Servicio de Inmunologia
Hospital Nacional de Pediatria J. P. Garrahan
Buenos Aires, Argentina
srosenzweig at garrahan.gov.ar

On 11 Mar 2008 at 22:44, Richard L. Wasserman, M.D.,Ph.D. wrote:


> I received the following email from the mother of the patient described. 

> He had hypogammaglobulinemia and vaccine non-responsiveness as a young 

> child and was treated IV. Reevlaution at about age 12 again demonstrated 

> vaccine non-responsiveness but resolution of hypogammaglobulinemia. I 

> recommended stopping IVIG at that time but his parents opted to 

> contine.  He developed severe infusion related migraine and was treated 

> sub q for the past several years. Last spring, because he had done well 

> and was getting ready for college, I again stopped sub q IgG to 

> reevaluate him. He never returned for his lab studies. He had run away. 

> This is my first information about him. Any comments for a reply to his 

> mother?

> Thanks,

> Richard Wasserman

> Dallas

> 

> Dr Wasserman, our son has been a patient of yours since he was 2(he is now 18) and stopped taking gamma several months ago. When he was taking the gamma he would feel great after the treatment and by the end of the 3-4 weeks would feel bad....not necessarily sick but just felt bad. His energy would be down and his body hurt. Since he has been off of the gamma he has had a dramatic and devestating change in his personality and ability to function. Not just the I am a teenager and my parents dont know anything 

change or rebellion. He is presently on his 3rd court order commitment to the psychiatric hospital. He has also been arrested twice in the last 2 months after which they send him to the hospital. He has been diagnosed with major depression, bi-polar, anxiety, ADD, & OCD. He looses major periods of time that he cant account for anywhere from a few days to three weeks. He is now taking several medications a day to help with his various new medical diagnoses. 

> 

> Have you ever seen a patient that the gamma helped with how they felt and acted and then when stopped had this type of effect?  Our whole family is just beaten down from his behavior and hospital stays over the past 4 months. The last day he acted like himself and he could hold a normal conversation was October 31st. I remember the day clearly as what began to happened a couple of days later is hard to comprehend.The hospital checks him for drugs each time he is admitted and his is always clean. 

> 

> The therapist tells me I am trying to find a logical answer to an illogical situation. Which I understand but dont want to overlook anything that might help with Phillip's outcome. 

> 

> Thanks for any ideas you might have.

> 

> 

> 

> 

> 

> 

> -- 

> No virus found in this incoming message.

> Checked by AVG. 

> Version: 7.5.518 / Virus Database: 269.21.7/1325 - Release Date: 11/03/2008 01:41 p.m.

>