[PAGID] Patient with recurrent abscesses

[Abraham, Roshini S., Ph.D.]

Thanks so much for this information.

 

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From: pagid-bounces at list.clinimmsoc.org [mailto:pagid-bounces at list.clinimmsoc.org] On Behalf Of Ballas, Zuhair
Sent: Monday, July 21, 2008 8:43 AM
To: pagid at list.clinimmsoc.org
Subject: Re: [PAGID] Patient with recurrent abscesses

 

I believe ARUP labs in Utah  run an enzymatic test for PK

 

________________________________

From: pagid-bounces at list.clinimmsoc.org [mailto:pagid-bounces at list.clinimmsoc.org] On Behalf Of Abraham, Roshini S., Ph.D.
Sent: Monday, July 21, 2008 5:01 AM
To: pagid at list.clinimmsoc.org
Subject: Re: [PAGID] Patient with recurrent abscesses

 

Thanks for the note below.....unfortunately we do not have a test available in our lab for neutrophil PK....I wonder whether there is a clinical lab in the US that tests for the enzyme function?

 

Roshini

 

 

Roshini S. Abraham

Mayo Clinic

 

________________________________

From: pagid-bounces at list.clinimmsoc.org [mailto:pagid-bounces at list.clinimmsoc.org] On Behalf Of Oner Ozdemir
Sent: Monday, July 21, 2008 2:35 AM
To: pagid at list.clinimmsoc.org
Cc: Abraham, Roshini S., Ph.D.
Subject: Re: [PAGID] Patient with recurrent abscesses

 

In the literature (below); neutrophil PK deficiency described earlier with recurrent staph infections. 

 

Burge PS <http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Burge%20PS%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus> , Johnson WS <http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Johnson%20WS%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus> , Hayward AR <http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Hayward%20AR%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus> .Neutrophil pyruvate kinase deficiency with recurrent staphylococcal infections: first reported case.Br Med J. 1976 Mar 27;1(6012):742-5. A woman with an intracellular killing defect in the neutrophils had neutrophil pyruvate kinase deficiency. She had had recurrent staphylococcal infections throughout her life. The enzyme present was unstable and its kinetics were abnormal.PMID: 4193 [PubMed - indexed for MEDLINE].. PMCID: PMC1639201

 

Öner Özdemir, MD
Assoc. Prof. Pediatrics
Sema Teaching and Training Hospital (Private)
Dragos, Maltepe-Kartal, İSTANBUL -TÜRKİYE 



 

On 7/18/08, Abraham, Roshini S., Ph.D. <> wrote: 

We have a 43 year old woman from the Northwest United States that has had recurrent staphylococcal abscesses (non-MRSA) since age 9.  These have been located in her groin, under and on her arms, abdomen, behind her ear and generally develop within 12-24 hours.  She has required multiple incision, drainage, and packing procedures and has take prophylactic antibiotics without significantly decreasing the frequency of their occurrence.  She is otherwise healthy except for cigarette smoking, peripheral vascular disease, urinary stress incontinence, and irritable bowel syndrome.  She denies eczema.  Her father, his sisters, and her paternal grandmother all have the same problem though to a lesser degree.  Physical exam is notable only for 1 cm pink raised lesions in her groin area, none are actively draining or fluctuant.  Her immune testing to date includes normal IgA, IgM, and IgG.  She has had a normal oxidative burst test and normal neutrophil chemotaxis.  She does not have anemia, thrombocytopenia or neutropenia.  Her ALC is also normal.  No evidence of respiratory or other infections, lymphadenopathy, malnutrition etc.  

 

We would appreciate your comments and advice.

 

 

Mathew A. Rank, MD, Mayo Clinic, Rochester, MN

Roshini S. Abraham

 

 

 

 

 

 

 

 

Roshini Sarah Abraham, Ph.D., D(ABMLI)

Consultant, Div. of Clinical Biochemistry & Immunology
Assistant Professor of Medicine & Lab. Medicine & Pathology 
Director 
Cellular and Molecular Immunology Laboratory 
Department of Laboratory Medicine and Pathology 
Hilton 210 e 
Mayo Clinic 
200 1st St SW 
Rochester, MN-55905 
Ph: 507-266-9292 
Ph (Secy): 507-284-4055 
Fax: 507-266-4088 

 




-- 
Öner Özdemir, MD
Assoc. Prof. Pediatrics
Sema Teaching and Training Hospital (Private)
Dragos, Maltepe-Kartal, İSTANBUL -TÜRKİYE 

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