[PAGID] IVIG for ParvoB19?

[Haines, Kathleen M.D.]

Rash of Systemic Onset JIA?

 

Kathleen A. Haines, MD

Section Chief, Pediatric Immunology

Pediatric Rheumatology and Immunology

Hackensack University Medical Center

30 Prospect Ave.

Hackensack, NJ 07601

 

Tel: 201-996-5306

Fax: 201-996-9815

 

________________________________

From: pagid-bounces at list.clinimmsoc.org
[mailto:pagid-bounces at list.clinimmsoc.org] On Behalf Of Berger, Melvin
Sent: Monday, March 09, 2009 2:41 PM
To: pagid at list.clinimmsoc.org
Subject: RE: [PAGID] IVIG for ParvoB19?

 

Have you done a marrow ?  Have you looked at ferritin, etc to R/O
hematophagocytic/macrophage activation type syndrome ?  

 

I assume he is Coombs negative. Any evidence of something like ALPS ?
Jack Bleesing found an unusual mutation in a patient of ours who had
recurrent coombs-negative hemolytic anemia and a huge spleen causing
abdominal pain, but never had lymphadenopathy

 

Melvin Berger, M.D., Ph.D.

Professor of Pediatrics and Pathology

Case Western Reserve University

phone 216 844 3237

 

Director, Jeffrey Modell Center for Primary Immune Deficiencies

Division of Allergy-Immunology

Rainbow, Babies and Children's Hospital

University Hospitals of Cleveland

RB&C Rm 504, MS 6008B

11100 Euclid Ave.

Cleveland, OH 44106

 

________________________________

From: pagid-bounces at list.clinimmsoc.org on behalf of raas0027 at umn.edu
Sent: Mon 3/9/2009 2:18 PM
To: pagid at list.clinimmsoc.org
Subject: [PAGID] IVIG for ParvoB19?

Dear Colleagues,

I have a 13 year old male with 6p+4q- translocation and a host of
associated clinical issues.


>From an immune stadpoint, he has T-cell lymphopenia with a baseline CD3

of
under 400/uL. Clinically he has done well from an infection standpoint
for
many years. He has normal mitogens as well as normal quantitative and
qualitative antibody response. Lots of other studes performed but to be
brief, were normal.

After 30+ days of nightly fever and modest splenomegaly, a id/heme
workup
revealed only a positive PCR for parvovirus b19 in the peripheral blood.

The question of IVIG as treatment for Parvovirus B19 in a lymphopenic
patient was raised. I have never used IVIG in a case like this.
Literature
data is spartan.

Any expererience out there?

Thank you!

Regards,

Jason

--


Jason P. Raasch, MD

Midwest Immunology Clinic
City Center Professional Building
15700 37th St NE
Suite 110
Plymouth, MN 55446

Office: 763.577.0008
FAX: 763.577.0192
raas0027 at umn.edu

**************************************************************************************************
-------------- next part --------------
An HTML attachment was scrubbed...
URL: <http://seven.pairlist.net/mailman/private/pagid/attachments/20090309/e02b38f6/attachment.htm>