[PAGID] IVIG for ParvoB19?

[Daniel Conway]

We had a patient with deep AIDS, poor adherence to HAART, profound T
cell lymphopenia (<50 cells/mm3 for several years) who developed
severe anemia that persisted for months due to parvovirus.  He received
1 g/kg IVIg and then one month later received IVIg (at the same dose)
again.  His anemia resolved and he no longer had evidence of parvo by
molecular analysis in his blood.  



Dan

Sincerely, 
Daniel H. Conway, MD 
Asst. Professor of Pediatrics 
St. Christopher's Hospital for Children 
Drexel University College of Medicine 


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> From: raas0027 at umn.edu

> To: pagid at list.clinimmsoc.org

> Date: Mon, 9 Mar 2009 13:18:59 -0500

> Subject: [PAGID] IVIG for ParvoB19?

> 

> Dear Colleagues,

> 

> I have a 13 year old male with 6p+4q- translocation and a host of 

> associated clinical issues.

> 

> >From an immune stadpoint, he has T-cell lymphopenia with a baseline CD3 of 

> under 400/uL. Clinically he has done well from an infection standpoint for 

> many years. He has normal mitogens as well as normal quantitative and 

> qualitative antibody response. Lots of other studes performed but to be 

> brief, were normal.

> 

> After 30+ days of nightly fever and modest splenomegaly, a id/heme workup 

> revealed only a positive PCR for parvovirus b19 in the peripheral blood.

> 

> The question of IVIG as treatment for Parvovirus B19 in a lymphopenic 

> patient was raised. I have never used IVIG in a case like this. Literature 

> data is spartan.

> 

> Any expererience out there?

> 

> Thank you!

> 

> Regards,

> 

> Jason

> 

> -- 

> 

> 

> Jason P. Raasch, MD

> 

> Midwest Immunology Clinic

> City Center Professional Building

> 15700 37th St NE

> Suite 110

> Plymouth, MN 55446

> 

> Office: 763.577.0008

> FAX: 763.577.0192

> raas0027 at umn.edu

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