[PAGID] patient who lacks long-term memory antibody responses

[Dewton Vasconcelos]

We have seen such immunological behavior in patients relative of CVID 
patients without overt hypogammaglobulinemia.
Moreover, it's important to think about CD21 deficiency, that could lead 
to rapid decrease of antibody titers and a leaky memory. CD21 decreases 
the antigen requirement to induce a secondary response by up to 10,000 fold.

Best regards,

Dewton
University of São Paulo

Howard M Lederman escreveu:

>

> I have a fascinating  12 yr old male patient with a history of 

> recurrent infections (mostly upper and lower respiratory tract).  No 

> individual infection has been overwhelmingly severe, but the sum of 

> all infections leads to a significant number of school absences.

>

> He has low IgG and IgM levels with normal IgA levels.  He makes normal 

> IgG antibody responses to a wide variety of vaccines, but does not 

> seem to be able to maintain long-term immunity.  (See attached 

> spreadsheet.  Sheet 1 tabulates the antibody and immunglobulin levels; 

> sheet 2 lists the immunizations.)

>

> Is this a pattern that others have seen?    I am open to any ideas for 

> further evaluation.  Would anyone offer this child gamma globulin? 

>

> Howard

> Howard M. Lederman, M.D., Ph.D.

> Professor of Pediatrics, Medicine and Pathology

> Division of Pediatric Allergy and Immunology

> Johns Hopkins Hospital - CMSC 1102

> 600 N. Wolfe Street

> Baltimore, MD 21287-3923

> Phone: 410-955-5883

> Fax: 410-955-0229

> Email: Hlederm1 at jhem.jhmi.edu

>

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