[PAGID] Vitiligo postBMT and right ptosis

[Nacho Gonzalez]

Somebody can help us with this clinical case:?

13 y.o. male. RAG deficiency + allogenic bone marrow transplantation
(haploidentical sibbling. HLA B7, A26, A28, Cw*00, B14, B35, DR7,
DR14) without complications except for extensive vitiligo, starting 8 years
after transplantation. Since the last year asthenia, and since the last
month right ptosis. Neurologist clinically confirms myasthenia gravis
(Pending Antibodies against ACh-Receptor and Tensilon´s Test (Edrophonium)).
No other signs of cGVHD.
Questions:
These are enough criteria to consider it cGVHD (extensive skin +
neuromuscular junction)?
Do you have experience with the management of myasthenia gravis postBMT?

Thanks.
Luis Ignacio Gonzalez Granado. Immunodeficiencies Division. Hospital 12
octubre. Madrid. Spain.
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