[PAGID] (PAGID) Menactra vaccination

[Pere Soler Palacin]

 Dear colleague, we have tried unsuccesfully to use it in our hospital.
Anyway this work from Rezaei from Iran () may be helpful since methods are
well described

    

Primary antibody deficiencies are characterized by decreased serum levels
of immunoglobulin isotypes and increased susceptibility to infection by
various microorganisms including encapsulated bacteria. This study was
performed in order to evaluate bactericidal antibody response of these
patients to polysaccharide meningococcal vaccine. Twenty-four antibody
deficient children of mean age 11.2+/-3.5 years, and 15 sex and age-matched
healthy volunteers were enrolled. All subjects received meningococcal
polysaccharide vaccine A+C; blood samples were collected before vaccination
and 3 weeks after vaccination. Following vaccination, the serum
bactericidal antibody (SBA) geometric mean titre was significantly
increased compared to the prevaccination level in the patient group (8.98
versus 1.63, Por=4-fold from pre- to post-vaccination), whereas only 16 of
24 patients (66.6%) had a protective response (P=0.014). The non-responder
patients included 5 cases with common variable immunodeficiency, two cases
with hyper IgM syndrome, and one case with IgG subclass deficiency. This
study indicates that some patients with primary antibody deficiencies can
produce protective post-vaccination titres similar to the normal
population, despite the common perception that patients with primary
antibody deficiencies respond poorly to vaccination. This supports the use
of polysaccharide-containing vaccines in these patients. Yours,

 Dr. P. Soler Palacín 
 Pediatric Infectious Diseases and Immunodeficiencies Unit 
 Vall d'Hebron Hospital 
 Barcelona, Spain 
 Tel: 0034934893140 
 Fax: 0034934893039

 On Fri 14/05/10 21:13 , "Kimberly Risma" Kimberly.Risma at cchmc.org sent:
  Dear Colleagues, I have a new patient (teenager) that is already on IVIG
that I would like to test for specific response to vaccination. We do not
have access to a neoantigen so I was wondering if anyone ever tried using
the conjugated Meningitis vaccine (Menactra in the U.S.) and measuring pre
and post titers. My rationale is that I would expect absent to minimum
titers in the IVIG preparations. If you have had any success, can you
indicate which lab will measure titers in an informative manner? What age
child have you used this approach? Thanks, Kim

 Kimberly Risma MD, PhD
 Assistant Professor
 Allergy Immunology
 Childrens Hospital Medical Center
 3333 Burnet Ave, mlc 2000
 Cincinnati, OH 45229

 
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