[PAGID] Eosinophilic abscesses in a CGD patient. .
Sabiha Anis
sabiha_anis at hotmail.com
Tue Jun 8 01:54:23 EDT 2010
I agree with Dr Ashish on the reliability of Quantiferon Gold test in this case. If the patient is giving a strong positive result with PPD then this test will not resolve the issue if there is already a hyerreactive immune system.
Regards
Sabiha Anis
Clinical Immunologist
Sindh Institute of Urology and Transplantation
Karachi, Pakistan
> Date: Wed, 2 Jun 2010 13:48:54 -0400
> From: Ashish.Kumar at cchmc.org
> To: pagid at list.clinimmsoc.org
> Subject: Re: [PAGID] Eosinophilic abscesses in a CGD patient. .
>
> Is Quantiferon useful/reliable in patients with CGD or 1L-12/IFN-g
> pathway defects? Specifically, is the negative predictive value good
> enough?
> Ashish
>
> Ashish Kumar, MD, PhD
> Assistant Professor
> Cincinnati Children's Hospital Medical Center
> Cincinnati, OH
>
>
>
> >>> Howard Lederman <hlederm1 at jhmi.edu> 6/2/2010 1:36 PM >>>
> Mary Ellen,
>
> Quantiferon gold is a commercial in vitro test. Whole blood is mixed
> with TB Ags. Read-out is interferon-gamma production. Here's a link to
> a page at the CDC website.
> http://www.cdc.gov/tb/publications/factsheets/testing/QFT.htm
>
> Howard
> Howard M. Lederman, M.D., Ph.D.
> Professor of Pediatrics, Medicine and Pathology
> Division of Pediatric Allergy and Immunology
> Johns Hopkins Hospital - CMSC 1102
> 600 N. Wolfe Street
> Baltimore, MD 21287-3923
> Phone: 410-955-5883
> Fax: 410-955-0229
> Email: Hlederm1 at jhmi.edu
>
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> -----Original Message-----
> From: pagid-bounces at list.clinimmsoc.org
> [mailto:pagid-bounces at list.clinimmsoc.org] On Behalf Of Conley, Mary
> Ellen
> Sent: Wednesday, June 02, 2010 1:15 PM
> To: 'pagid at list.clinimmsoc.org'
> Subject: Re: [PAGID] Eosinophilic abscesses in a CGD patient. .
>
> Hi Steve,
> Can you explain to some of us ignorant (but interested) folks what a
> quantiferon gold is?
> Mary Ellen
>
>
> Mary Ellen Conley, MD
> Department of Immunology/ Mail Stop 351
> St. Jude Children's Research Hospital
> 262 Danny Thomas Place
> Memphis, TN 38105-3678
> FAX 901-595-3977
> TEL 901-595-2576
>
>
> -----Original Message-----
> From: pagid-bounces at list.clinimmsoc.org
> [mailto:pagid-bounces at list.clinimmsoc.org] On Behalf Of Holland,
> Steven (NIH/NIAID) [E]
> Sent: Wednesday, June 02, 2010 11:41 AM
> To: Howard Lederman; pagid at list.clinimmsoc.org
> Subject: Re: [PAGID] Eosinophilic abscesses in a CGD patient. .
>
> Was the material cultured for Granulibacter and similar organisms? I
> doubt Churg Straus but stopping mesalamine in the short run seems
> harmless enough. Necrotizing granulomatous abscesses in CGD should be
> due to a bacterial or fungal infection. I would treat him empirically
> with ceftriaxone and vori, adding meropenem if he were acutely ill. If
> he is from Maryland then M. marinum or another NTM could do this,
> although 15 mm is pretty big. I would send a quantiferon gold.
>
> Steve
>
>
> On 6/2/10 12:29 PM, "Howard Lederman" <hlederm1 at jhmi.edu> wrote:
>
> Colleagues,
>
> I have a 4 ½ year old male patient who was diagnosed with chronic
> granulomatous disease at 5 weeks of age after presentation with
> bilateral neck masses (cervical lymphadenitis caused by
> methicillin-sensitive S. aureus). He has had multiple episodes of
> cervical lymphadenitis, requiring parenteral antibiotics. He is
> maintained on interferon gamma (3x/week) and Ciprofloxacin (TMP/SMZ
> caused leukopenia and thrombocytopenia). Other medications are iron and
> multivitamin daily.
>
> He has a history of bloody stools in early infancy thought to be due to
> cow's milk enterocolitis. Symptoms resolved when he was switched to an
> elemental formula, and a colonoscopy while on Elecare was normal. He
> has introduced to cow's milk at 12 months of age without problems.
>
> When he was 3 ½ yrs old, he had bloody stools and poor weight gain.
> Cultures, and stool test for ova and parasites were normal. RASTs to
> food allergens were negative. Milk elimination did not help. In Jan
> 2010, EGD showed chronic duodenitis, and colonoscopy showed many areas
> with crypt distortion, prominent lamina propria eosinophils and rare
> intraepithelial eosinophils. Granulomas were not seen. He was started
> on Apriso (mesalamine) in early April to treat inflammatory bowel
> disease.
>
> At the end of April, he developed fevers to 103 F with no obvious
> source. Over a two week period, his WBC increased to WBC 30,000 with
> 44% polys, 43% lymphs and 6% eos. CRP 16 mg/dL. He then developed
> abdominal distension and a new hydrocele over a short period of time,
> due to bulky lymphadenopathy involving the mesentery and
> retroperitoneum. A PPD was placed and was positive with 15 mm
> induration.
>
> He underwent an excisional biopsy of several mesenteric nodes so that
> we could identify the mycobacterium that we were confident was the cause
> of his acute symptoms. No acid fast organisms were seen in the lymph
> nodes. Cultures are still negative but it has been only 2 weeks so
> far. However, the lymph node histology was a complete surprise to us.
> There were granulomas, but the center of many of them were filled with
> abscesses of eosinophils! [The CIS has posted a photomicrograph of
> the lymph node biopsy at
> http://www.clinimmsoc.org/UserFiles/file/pagid_lederman.pdf]
>
> Our pathologists favor a diagnosis of Churg-Strauss based only upon the
> histology. The Infectious Diseases group thinks that this represents
> a drug hypersensitivity reaction and wants us to stop Apriso. Neither
> diagnosis explains the positive PPD.
>
> Does anyone have a differential diagnosis for this?
>
> Howard
> Howard M. Lederman, M.D., Ph.D.
> Professor of Pediatrics, Medicine and Pathology Division of Pediatric
> Allergy and Immunology Johns Hopkins Hospital - CMSC 1102 600 N. Wolfe
> Street Baltimore, MD 21287-3923
> Phone: 410-955-5883
> Fax: 410-955-0229
> Email: Hlederm1 at jhmi.edu <mailto:Hlederm1 at jhem.jhmi.edu>
>
> WARNING: E-mail sent over the Internet is not secure.
> Information sent by e-mail may not remain confidential.
>
> DISCLAIMER: This e-mail is intended only for the individual to whom it
> is addressed. It may be used only in accordance with applicable laws. If
> you received this e-mail by mistake, please notify the sender and
> destroy the e-mail.
>
>
>
> Chief, Laboratory of Clinical Infectious Diseases CRC B3-4141 MSC 1684
> Bethesda, MD 20892-1684
> 301-402-7684 (v)
> 301-480-4508 (fax)
> smh at nih.gov
> Assistant: Adrienne Woodworth
> 301-451-9019 (v)
> 301-480-4506 (fax)
> awoodworth at niaid.nih.gov
>
>
>
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