[PAGID] APECED/APS I and Renal Failure

[Kirkpatrick, Charles]

Is the renal disease possibly due to treatment with amphotericin B for candidiasis?

Chuck Kirkpatrick

From: pagid-bounces at list.clinimmsoc.org [mailto:pagid-bounces at list.clinimmsoc.org] On Behalf Of Cunningham-Rundles, Charlotte
Sent: Monday, August 23, 2010 10:28 AM
To: PAGID
Subject: Re: [PAGID] APECED/APS I and Renal Failure

Ken, we have one of ours in this boat. Same question. I have no idea how to handle it. The mom will be the kidney donor.

Charlotte

Charlotte Cunningham-Rundles MD PhD
Departments of Medicine, Pediatrics
The Immunology Institute
Mount Sinai School of Medicine
1425 Madison Avenue,
New York City, New York, 10029
212 659 9268 (phone)
212 987 5593 (fax)

________________________________
From: "Paris, Kenneth" <kparis at lsuhsc.edu>
Reply-To: PAGID <pagid at list.clinimmsoc.org>
Date: Mon, 23 Aug 2010 11:25:07 -0500
To: PAGID <pagid at list.clinimmsoc.org>
Subject: [PAGID] APECED/APS I and Renal Failure

Hi,

I was recently consulted regarding a young girl with APS Type I.  She has all the typical features as well as the endocrinopathies, and her clinical course has now been complicated by kidney disease that has been characterized as chronic interstitial nephropathy.  (Our other APS patient has renal issues, but in her case the underlying cause is most likely nephrocalcinosis caused by the large Ca++ supplementation she requires.)  This new girl is on her way to needing dialysis, and our nephrology division is contemplating the idea of renal transplantation in the future.

I found one citation from 2005, and from my brief search it seems to be the only published report of RF/transplant in this disease:    J Clin Endocrinol Metab. <javascript:AL_get(this, 'jour', 'J Clin Endocrinol Metab.');> 2006 Jan;91(1):192-5. Epub 2005 Nov 1. Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy syndrome with renal failure: impact of posttransplant immunosuppression on disease activity. Ulinski T </pubmed?term=%22Ulinski%20T%22%5BAuthor%5D> , Perrin L </pubmed?term=%22Perrin%20L%22%5BAuthor%5D> , Morris M </pubmed?term=%22Morris%20M%22%5BAuthor%5D> , Houang M </pubmed?term=%22Houang%20M%22%5BAuthor%5D> , Cabrol S </pubmed?term=%22Cabrol%20S%22%5BAuthor%5D> , Grapin C </pubmed?term=%22Grapin%20C%22%5BAuthor%5D> , Chabbert-Buffet N </pubmed?term=%22Chabbert-Buffet%20N%22%5BAuthor%5D> , Bensman A </pubmed?term=%22Bensman%20A%22%5BAuthor%5D> , Deschênes G </pubmed?term=%22Desch%C3%AAnes%20G%22%5BAuthor%5D> , Giurgea I </pubmed?term=%22Giurgea%20I%22%5BAuthor%5D>

Does anyone have experience with this complication in APS patients, or management suggestions considering the underlying defect?

Ken

Kenneth Paris MD, MPH
Assistant Professor of Pediatrics
A/I Fellowship Training Program Director
Division of Allergy and Immunology
JM Diagnostic Center for PI
LSU Health Sciences Center
Children's Hospital of New Orleans

Mail:
200 Henry Clay Avenue
Children's Hospital
Research Institute for Children 4th Floor
New Orleans, LA 70118
Phone:  504-896-9589
Fax:  504-896-9311
Email:  kparis at lsuhsc.edu <mailto:kparis at lsuhsc.edu>

The information contained in this e-mail is privileged and confidential and is intended only for the use of the addressee(s) indicated above. Use or disclosure of information e-mailed in error is respectfully prohibited. If you have received this e-mail in error, please contact the sender and immediately delete the original message or you may call 504-896-9589. Thank you.
-------------- next part --------------
An HTML attachment was scrubbed...
URL: <http://seven.pairlist.net/mailman/private/pagid/attachments/20100823/73eaf723/attachment-0001.htm>