[CIS-PAGID] Antwort: Re: Ivasive pneumococcal disease.

[Church, Joseph]

Thank you all.

 

I forgot to list that the patient has a spleen by ultrasonography and no H-J bodies on peripheral blood smear.  

 

Will a patient with properdin deficiency have a normal AH50?

 

Joe Church

 

________________________________

From: pagid-bounces at list.clinimmsoc.org [mailto:pagid-bounces at list.clinimmsoc.org] On Behalf Of stephan.ehl at uniklinik-freiburg.de
Sent: Wednesday, March 16, 2011 12:07 PM
To: pagid
Subject: Re: [CIS-PAGID] Antwort: Re: Ivasive pneumococcal disease.

 

Ivemark syndrome and there are probably others, ST

________________________________

  Von: "Saxon, Andy M.D." [ASaxon at mednet.ucla.edu]
  Gesendet: 16.03.2011 11:43 MST
  An: "'pagid at list.clinimmsoc.org'" <pagid at list.clinimmsoc.org>
  Betreff: Re: [CIS-PAGID] Antwort: Re:  Ivasive pneumococcal disease.

 

Absolutely good thought as I've seen that  but it would be strange if both sibs had no spleen. Is there a congenital absence of  spleen in some syndrome?  

 

Andy Saxon, MD

UCLA

 

________________________________

From: pagid-bounces at list.clinimmsoc.org [mailto:pagid-bounces at list.clinimmsoc.org] On Behalf Of stephan.ehl at uniklinik-freiburg.de
Sent: Wednesday, March 16, 2011 11:12 AM
To: pagid at list.clinimmsoc.org
Subject: [CIS-PAGID] Antwort: Re: Ivasive pneumococcal disease.

Spleen is present and functional?



Beste Grüße 

Prof. Dr. Stephan Ehl
Wissenschaftlicher Direktor

CCI - Centre of Chronic Immunodeficiency
UNIVERSITÄTSKLINIKUM FREIBURG 
Breisacher Str. 117 - 2. OG, 79106 Freiburg i. Brsg., Germany
phone: +49(0)761.270-7730
Sekretariat +49(0)761.270-7755 fax +49(0)761.270-7760
e-mail: stephan.ehl at uniklinik-freiburg.de



-----pagid-bounces at list.clinimmsoc.org schrieb: ----- 

	An: pagid at list.clinimmsoc.org
	Von: Nacho Gonzalez 
	Gesendet von: pagid-bounces at list.clinimmsoc.org
	Datum: 16.03.2011 07:07PM
	Betreff: Re: [CIS-PAGID] Ivasive pneumococcal disease.

	Dear Joe,

	
	has this patient detectable levels of properdin (either by radial immunodiffusion or Western blot) ?

	 

	Regards

	 

	Luis Ignacio Gonzalez-Granado

	Immunodeficiencies Unit

	Hospital 12 octubre. Madrid. Spain.

	2011/3/16 Church, Joseph <JChurch at chla.usc.edu>

	Colleagues:

	 

	I have evaluated a 4yo boy who had pneumococcal pneumonia + empyema at 2.5yo.

	 

	His fraternal twin died at 6mo from pneumococcal meningitis.

	 

	Normal labs have included:

	-          CBCs

	-          IgG, A, M, E

	-          Tetanus, Hib, pneumococcal vaccine responses (including persistently +19/23 serotypes following Pneumovax)

	-          CH50

	-          AH50

	-          T, B numbers

	-          Mitogen and antigen LPAs

	-          HIV PCR

	-          Mannose binding lectin 

	-          TLR function (measured at IBT Labs).

	 

	What am I missing?

	 

	Joe Church

	Clinical Immunology and Allergy

	Children's Hospital Los Angeles

	 

	 

	
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