[CIS-PAGID] CVID + LIP

[Fleisher, Thomas (NIH/CC/DLM) [E]]

Jack,
Are you planning on writing this up? Nicki is here and we have put together a full day for her to get a "flavor" of the NIH Intramural Clinical Research program. 
Thanks,
Tom

Thomas A. Fleisher, M.D.
Chief, Department of Laboratory Medicine
NIH Clinical Center
301 496-5668 (T)
301 402-1612 (F)
-----Original Message-----
From: Routes, John [mailto:jroutes at mcw.edu] 
Sent: Friday, July 22, 2011 8:32 AM
To: pagid at list.clinimmsoc.org
Subject: Re: [CIS-PAGID] CVID + LIP

We have treated over ten patients with combination chemotherapy consisting of rituxin and azathioprine with outstanding results no infections and in many cased complete or near complete clearing.

Sent from my Verizon Wireless BlackBerry

________________________________
From: Terri Tarrant <tarra002 at gmail.com>
Sender: "pagid-bounces at list.clinimmsoc.org" <pagid-bounces at list.clinimmsoc.org>
Date: Fri, 22 Jul 2011 06:16:47 -0500
To: pagid at list.clinimmsoc.org<pagid at list.clinimmsoc.org>
ReplyTo: "pagid at list.clinimmsoc.org" <pagid at list.clinimmsoc.org>
Subject: Re: [CIS-PAGID] CVID + LIP

Yes, we have 3 cases that responded well (2 with CVID and 1 idiopathic LIP).  We used the Eisenberg protocol of 1 g IV day 0 and day 14 with 100 mg IV solumedrol pre-med.  We did not use in combination with other drugs.  We did not see an increase in infections.  All patients needed redosing at 9-12 month intervals.

Terri Tarrant

On Thu, Jul 21, 2011 at 10:07 PM, Church, Joseph <JChurch at chla.usc.edu<mailto:JChurch at chla.usc.edu>> wrote:
Colleagues:

A 60yo female with long term CVID has had lymphoid interstitial pneumonitis that was biopsy documented in 2005.

She had developed worsening of symptoms over the past 6 months.

She is trying to avoid increasing her prednisone, currently at 10mg/d, because of coronary artery disease and hypertension; she could not tolerate CellCept.

Has anyone tried Rituximab in this setting?

Joe Church, MD
Children's Hospital Los Angeles



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Terri Tarrant, MD
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Thurston Arthritis Research Center
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