[CIS-PAGID] CVID + LIP

[Notarangelo, Luigi]

I would be interested to join as well

Gigi

Luigi D. Notarangelo
Division of Immunology
Children's Hospital Boston 
Sent from my Verizon Wireless BlackBerry

-----Original Message-----
From: "Nelson, Robert P Jr" <ronelson at iupui.edu>
Sender: "pagid-bounces at list.clinimmsoc.org"
	<pagid-bounces at list.clinimmsoc.org>
Date: Fri, 22 Jul 2011 18:18:15 
To: pagid at list.clinimmsoc.org<pagid at list.clinimmsoc.org>
Reply-To: "pagid at list.clinimmsoc.org" <pagid at list.clinimmsoc.org>
Subject: Re: [CIS-PAGID] CVID + LIP


Sounds good to me; we would participate.  Bob
________________________________________
From: pagid-bounces at list.clinimmsoc.org [pagid-bounces at list.clinimmsoc.org] on behalf of David Rawlings [drawling at u.washington.edu]
Sent: Friday, July 22, 2011 5:38 PM
To: pagid at list.clinimmsoc.org
Subject: Re: [CIS-PAGID] CVID + LIP

As Jack and I have discussed previously, our group in Seattle would be keen
to participate in a trial- I suggest designing a 2 arm protocol eg Ritux
with or without Aza.
David

-----Original Message-----
From: pagid-bounces at list.clinimmsoc.org
[mailto:pagid-bounces at list.clinimmsoc.org] On Behalf Of Nelson, Robert P Jr
Sent: Friday, July 22, 2011 11:15 AM
To: pagid at list.clinimmsoc.org
Subject: Re: [CIS-PAGID] CVID + LIP

What about considering a mutlicenter clinical trial so we could contibute
our patients to an organized effort?  Bob
________________________________________
From: pagid-bounces at list.clinimmsoc.org [pagid-bounces at list.clinimmsoc.org]
on behalf of Fleisher, Thomas (NIH/CC/DLM) [E] [TFleishe at cc.nih.gov]
Sent: Friday, July 22, 2011 10:32 AM
To: Routes, John; pagid at list.clinimmsoc.org
Subject: Re: [CIS-PAGID] CVID + LIP

Sorry for copying all on a simple question to Jack.

Thomas A. Fleisher, M.D.
Chief, Department of Laboratory Medicine
NIH Clinical Center
301 496-5668 (T)
301 402-1612 (F)

-----Original Message-----
From: Routes, John [mailto:jroutes at mcw.edu]
Sent: Friday, July 22, 2011 8:32 AM
To: pagid at list.clinimmsoc.org
Subject: Re: [CIS-PAGID] CVID + LIP

We have treated over ten patients with combination chemotherapy consisting
of rituxin and azathioprine with outstanding results no infections and in
many cased complete or near complete clearing.

Sent from my Verizon Wireless BlackBerry

________________________________
From: Terri Tarrant <tarra002 at gmail.com>
Sender: "pagid-bounces at list.clinimmsoc.org"
<pagid-bounces at list.clinimmsoc.org>
Date: Fri, 22 Jul 2011 06:16:47 -0500
To: pagid at list.clinimmsoc.org<pagid at list.clinimmsoc.org>
ReplyTo: "pagid at list.clinimmsoc.org" <pagid at list.clinimmsoc.org>
Subject: Re: [CIS-PAGID] CVID + LIP

Yes, we have 3 cases that responded well (2 with CVID and 1 idiopathic LIP).
We used the Eisenberg protocol of 1 g IV day 0 and day 14 with 100 mg IV
solumedrol pre-med.  We did not use in combination with other drugs.  We did
not see an increase in infections.  All patients needed redosing at 9-12
month intervals.

Terri Tarrant

On Thu, Jul 21, 2011 at 10:07 PM, Church, Joseph
<JChurch at chla.usc.edu<mailto:JChurch at chla.usc.edu>> wrote:
Colleagues:

A 60yo female with long term CVID has had lymphoid interstitial pneumonitis
that was biopsy documented in 2005.

She had developed worsening of symptoms over the past 6 months.

She is trying to avoid increasing her prednisone, currently at 10mg/d,
because of coronary artery disease and hypertension; she could not tolerate
CellCept.

Has anyone tried Rituximab in this setting?

Joe Church, MD
Children's Hospital Los Angeles



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Terri Tarrant, MD
Assistant Professor of Medicine
Thurston Arthritis Research Center
Lineberger Cancer Center Member
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Chapel Hill, NC 27599
(919) 843-4727
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