[CIS-PAGID] response regarding A-T paitents

[Gatti, Richard A. M.D.]

Hi Anita and Joe,
The low T cell numbers and poor antibody responses are quite common and reported in the literature (O. Sanal et al).  The normal mitogen responses are a bit unusual but it depends a lot on whether one harvests the cells at 24 or 48 hours since the response per million cells is slow.  Opportunistic infections are not well documented in A-T patients.  This issue is also in the literature and was discussed at the 1984 A-T workshop (book by Gatti and Swift).  I think Erwin Gelfand or David Nelson brought the issue up and everyone agreed that they had not seen opportunistic infections in A-T patients.

Sorry for the short response.  Just rushing to the Hollywood bowl for a concert.

Richard A. Gatti, MD
Rebecca Smith Distinguished Professor
UCLA School of Medicine
Department of Pathology & Laboratory Medicine
675 Charles Young Drive South    Room 4-736
Macdonald Research Laboratories
Los Angeles, CA 90095-1732
1 310 825 7618 (tel/FAX)
rgatti at mednet.ucla.edu


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