[CIS-PAGID] hepatitis in CVID

[Michael Albert]

Have you checked for cryptosporidia?
Michel



PD Dr. med. Michael Albert

Oberarzt

Abteilung für Pädiatrische Hämatologie/Onkologie

Leiter der Stammzelltransplantation

Dr. von Haunersches Kinderspital der LMU

Lindwurmstr.4

80337 München

Tel: 089 5160 2785

Fax: 089 5160 4719

Am 28.10.2011 um 00:14 schrieb "Ashish Kumar" <Ashish.Kumar at cchmc.org>:


> 13 yr old female with H/O ITP and then recurrent pneumonia, including PCP, has hypogammaglobulinemia, low B cells (1%), high BAFF and now hepatitis with ALT 1000; liver biopsy shows florid infiltration with lymphocytes. She had been treated with steroids for her ITP which led to severe osteopenia and vertebral fractures, so was switched to MMF with good response in her platelet counts. She has normal numbers of T cells and they respond normally to mitogens and antigens. No viruses identified so far. So, regardless of what label we use (CVID with lympoproliferative hepatitis?), how would you treat her hepatitis without steroids?

>  

> Thanks!

> Ashish

>  

> Ashish Kumar MD, PhD

> Assistant Professor

> BMT/Immune Deficiency

> Cincinnati Children's Hospital