[CIS-PAGID] T - B - conditioning

[Nelson, Robert P Jr]

Hans,
As per Dr. Cowan's note.  Dick's contact info.  Bob


Richard A. Gatti, MD
Rebecca Smith Distinguished Professor
UCLA School of Medicine
Department of Pathology & Laboratory Medicine
675 Charles Young Drive South    Room 4-736
Macdonald Research Laboratories
Los Angeles, CA 90095-1732
1 310 825 7618 (tel/FAX)
rgatti at mednet.ucla.edu<mailto:rgatti at mednet.ucla.edu>



Robert P. Nelson Jr., MD
Professor of Medicine and Pediatrics
Divisions of Hematology/Oncology
535 Barnhill Dr. Ste 473
Indianapolis, IN  46202
Telephone: 317-948-1186
E-mail: ronelson at iupui.edu<mailto:ronelson at iupui.edu>
pager:  317-312-1773

From: pagid-bounces at list.clinimmsoc.org [mailto:pagid-bounces at list.clinimmsoc.org] On Behalf Of Cowan, Mort
Sent: Monday, May 21, 2012 2:02 PM
To: pagid at list.clinimmsoc.org
Subject: Re: [CIS-PAGID] T - B - conditioning

Hans,

It's only on a research basis and currently we're not accepting samples. I would recommend getting it done by Richard Gatti who has a CLIA approved lab at UCLA. The problem is you need to generated a fibroblast cell line to do the assay.

Mort

Morton J. Cowan, M.D.
Professor of Pediatrics
Chief, Allergy, Immunology, and Blood and Marrow Transplant Division
UCSF Children's Hospital, Room M659
505 Parnassus Ave
San Francisco, CA 94143-1278

Phone: 415-476-2188
FAX: 415-502-4867

**Confidentiality Notice** This email communication and any attachments may contain confidential and privileged information for the use of the designated recipients named above. Distribution, reproduction or any other use of this transmission by any party other than the intended recipient is prohibited.

From: pagid-bounces at list.clinimmsoc.org<mailto:pagid-bounces at list.clinimmsoc.org> [mailto:pagid-bounces at list.clinimmsoc.org]<mailto:[mailto:pagid-bounces at list.clinimmsoc.org]> On Behalf Of Ochs, Hans
Sent: Sunday, May 20, 2012 4:26 PM
To: 'pagid at list.clinimmsoc.org'
Subject: Re: [CIS-PAGID] T - B - conditioning

Hi, Mort,
Is your lab offering radiosensitivity assays?
hans

Hans D. Ochs, MD, Dr. med
Professor of Pediatrics | Jeffrey Modell Chair of Pediatric Immunology Research
Center for Immunity and Immunotherapies
Seattle Children's Research Institute | University of Washington

206-987-7450 OFFICE
206-987-7310  FAX
allgau at u.washington.edu<mailto:allgau at u.washington.edu>, hans.ochs at seattlechildrens.org<mailto:hans.ochs at seattlechildrens.org>

OFFICE   1900 Ninth Avenue, Seattle, WA 98101
MAIL      M/S C9S-7
WWW     seattlechildrens.org<http://seattlechildrens.org/>

Assistant:
Dawn Marie Pares
206-884-7418   OFFICE
dawnmarie.pares at seattlechildrens.org<mailto:dawnmarie.pares at seattlechildrens.org>

From: pagid-bounces at list.clinimmsoc.org<mailto:pagid-bounces at list.clinimmsoc.org> [mailto:pagid-bounces at list.clinimmsoc.org]<mailto:[mailto:pagid-bounces at list.clinimmsoc.org]> On Behalf Of Cowan, Mort
Sent: Thursday, May 17, 2012 9:19 AM
To: pagid at list.clinimmsoc.org<mailto:pagid at list.clinimmsoc.org>
Subject: Re: [CIS-PAGID] T - B - conditioning

The use of conditioning is really going to depend on the type of donor you have and whether or not there is radiation sensitivity. Have you looked for maternal engraftment? If positive, you could use the Mom as the donor with T cell depletion without any conditioning. That would be best given the infections. If you could find an 8/8 allele matched unrelated donor, that also might work without conditioning; you might not get B cell reconstitution but right now the child needs working T cells I would think in order to clear the CMV infection.

Mort

Morton J. Cowan, M.D.
Professor of Pediatrics
Chief, Allergy, Immunology, and Blood and Marrow Transplant Division
UCSF Children's Hospital, Room M659
505 Parnassus Ave
San Francisco, CA 94143-1278

Phone: 415-476-2188
FAX: 415-502-4867

**Confidentiality Notice** This email communication and any attachments may contain confidential and privileged information for the use of the designated recipients named above. Distribution, reproduction or any other use of this transmission by any party other than the intended recipient is prohibited.

From: pagid-bounces at list.clinimmsoc.org<mailto:pagid-bounces at list.clinimmsoc.org> [mailto:pagid-bounces at list.clinimmsoc.org]<mailto:[mailto:pagid-bounces at list.clinimmsoc.org]> On Behalf Of Nacho Gonzalez
Sent: Thursday, May 17, 2012 1:50 AM
To: pagid at list.clinimmsoc.org<mailto:pagid at list.clinimmsoc.org>
Subject: [CIS-PAGID] T - B - conditioning

Dear all,

I have a SCID patient (three month old female) T-B-NK + [Total lymph 590/uL, CD4+CD45RA+ 4/uL, CD4+CD45RA+CD31+ 5% (normal above 44%) , CD19 2 /uL, CD3+56- 466 /uL]   with rotavirus and CMV infection -with hemorrhagic enterocolitis. However her clinical condition is stable- (CMV viral load 122.000 copies/ml, on ganciclovir treatment -viral load under treatment pending- )
RAG1/2 genes: normal.
Artemis & ADA: pending, but no bird-like face, no bone abnormalities, normal uric acid and normal neurological examination). FOCI assay is pending

There isn´t identical familial donor.  Search for a non-familial donor: pending

I would like to know which ideal conditioning regimen do you suggest for this patient

Any other thoughts? Any input would be welcomed.

Thanks in advance for your time.

Luis Ignacio Gonzalez Granado
Immunodeficiencies Unit
Hospital 12 octubre. Madrid. Spain



CONFIDENTIALITY NOTICE: This e-mail message, including any attachments, is for the sole use of the intended recipient(s) and may contain confidential and privileged information protected by law. Any unauthorized review, use, disclosure or distribution is prohibited. If you are not the intended recipient, please contact the sender by reply e-mail and destroy all copies of the original message.
-------------- next part --------------
An HTML attachment was scrubbed...
URL: <http://seven.pairlist.net/mailman/private/pagid/attachments/20120521/17f11db9/attachment-0001.html>