[CIS PIDD] CGD and cutaneous ulcers

[Juan Carlos Aldave Becerra]

Dear Sara,
I was thinking about the benefit of GM-CSF topical therapy for chronic ulcers in CGD patients. Do you think this therapy may also help in mucocutaneous candidiasis in patients with Th17 cell problems (e.g. STAT1 gain-of-function mutations)?I wonder, perhaps we can attract neutrophils bypassing the need of Th17 cells. 
Kind regards,
Juan Carlos Aldave, MD
Allergy and Clinical Immunology
Rebagliati Martins National Hospital - Lima, Peru
Primary Immunodeficiency Committee of the Latin American Association of Immunology
WAO Special Committee on Eosinophil and Mast Cell Disorders
Clinical Immunology Committee of the IUIS


> From: sleo at cw.bc.ca

> To: jucapul_84 at hotmail.com

> Date: Sun, 12 Aug 2012 19:49:10 -0700

> Subject: RE: [CIS PIDD] CGD and cutaneous ulcers

> 

> Dear Juan,

> We're happy to help. Looking forward to hearing about the results!

> Regards,

> Sara

> 

> Sara Leo BSc, MD, FRCPC

> Pediatric Clinical Immunology and Allergy, PGY-5

> University of British Columbia

> BC Children's Hospital

> Email: sleo at cw.bc.ca

> Pager: 410-1447

> ________________________________________

> From: Juan Carlos Aldave Becerra [jucapul_84 at hotmail.com]

> Sent: August 10, 2012 7:41 PM

> To: Leo, Sara

> Subject: RE: [CIS PIDD] CGD and cutaneous ulcers

> 

> Dear Sara,

> 

> Thank you so much, yo are very kind. I will try to use G-CSF, I will advice you about the results.

> 

> Best regards,

> 

> Juan Carlos Aldave, MD

> Allergy and Clinical Immunology

> Rebagliati Martins National Hospital - Lima, Peru

> Primary Immunodeficiency Committee of the Latin American Association of Immunology

> WAO Special Committee on Eosinophil and Mast Cell Disorders

> Clinical Immunology Committee of the IUIS

> 

> 

> ________________________________

> From: sleo at cw.bc.ca

> To: jucapul_84 at hotmail.com

> CC: sturvey at cw.bc.ca

> Date: Fri, 10 Aug 2012 16:45:14 -0700

> Subject: RE: [CIS PIDD] CGD and cutaneous ulcers

> 

> Dear Juan,

> 

> Thank you for your email. Stuart used a topical application of GM-CSF as described by De Ugarte et al (paper attached). GM-CSF was filled with 50 ml sterile water for a final solution of 5 mcg/ml. Gauze dressings soaked with GM-CSF solution was applied to the lesion and changed every 8-12 h. Our patient was treated with GM-CSF for ~3-4 months. Unfortunately, we are not aware of any data about G-CSF as therapy for chronic skin ulcers. Hope that helps, and that your patient does well!

> 

> Sincerely,

> Sara

> 

> Sara Leo BSc, MD, FRCPC

> Pediatric Clinical Immunology and Allergy, PGY-5

> University of British Columbia

> BC Children's Hospital

> Email: sleo at cw.bc.ca

> Pager: 410-1447

> ________________________________

> From: pagid-bounces at list.clinimmsoc.org [pagid-bounces at list.clinimmsoc.org] On Behalf Of Juan Carlos Aldave Becerra [jucapul_84 at hotmail.com]

> Sent: August 10, 2012 3:48 PM

> To: pagid at list.clinimmsoc.org

> Subject: Re: [CIS PIDD] CGD and cutaneous ulcers

> 

> Dear Sara, what is the application method and frequency of treatment?

> 

> I have a patient with CGD and cutaneous ulcers. In Peru we only have G-CSF, may it replace GM-CSF?

> 

> Kind regards,

> 

> Juan Carlos Aldave, MD

> Allergy and Clinical Immunology

> Rebagliati Martins National Hospital - Lima, Peru

> Peruvian Group for Primary Immunodeficiencies

> WAO Special Committee on Eosinophil and Mast Cell Disorders

> Clinical Immunology Committee of the IUIS

> 

> 

> ________________________________

> From: sleo at cw.bc.ca

> To: pagid at list.clinimmsoc.org

> Date: Fri, 10 Aug 2012 14:18:16 -0700

> Subject: [CIS PIDD] CGD and cutaneous ulcers

> 

> Dear Colleagues,

> 

> My name is Sara Leo and I'm a 2nd year Pediatric Immunology/Allergy fellow at BC Children's Hospital in Vancouver, BC. About a year ago, Dr. Stuart Turvey wrote to PAGID to see if anyone had experience with using topical GM-CSF to treat CGD patients with cutaneous ulcers. Since then, we have successfully treated our patient with topical GM-CSF. We would like to put together a case series of CGD patients with cutaneous ulcers that have been treated with topical GM-CSF and would be interested in hearing about both failed and successful regimens. If anyone has experience with the above and would like to collaborate with us, we would love to hear from you.

> 

> Yours Sincerely,

> Sara

> 

> Sara Leo BSc, MD, FRCPC

> Pediatric Clinical Immunology and Allergy, PGY-5

> University of British Columbia

> BC Children's Hospital

> Email: sleo at cw.bc.ca

> Pager: 410-1447

 		 	   		  
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