[CIS PIDD] CGD and cutaneous ulcers

[Kobrynski, Lisa]

We have used topical G-CSF for skin ulcers in a couple of CGD patients - one of whom had skin lesions that were most similar to pyoderma gangrenosum.  We have also used infusions of granulocytes directly into a liver abscess - which worked very well.

LK



Lisa Kobrynski, MD, MPH
Associate Professor of Pediatrics
Marcus Professor of Immunology
Section, Allergy/Immunology
________________________________
From: pagid-bounces at list.clinimmsoc.org [pagid-bounces at list.clinimmsoc.org] on behalf of Leo, Sara [sleo at cw.bc.ca]
Sent: Friday, August 10, 2012 5:18 PM
To: pagid at list.clinimmsoc.org
Subject: [CIS PIDD] CGD and cutaneous ulcers

Dear Colleagues,

My name is Sara Leo and I'm a 2nd year Pediatric Immunology/Allergy fellow at BC Children's Hospital in Vancouver, BC. About a year ago, Dr. Stuart Turvey wrote to PAGID to see if anyone had experience with using topical GM-CSF to treat CGD patients with cutaneous ulcers. Since then, we have successfully treated our patient with topical GM-CSF. We would like to put together a case series of CGD patients with cutaneous ulcers that have been treated with topical GM-CSF and would be interested in hearing about both failed and successful regimens. If anyone has experience with the above and would like to collaborate with us, we would love to hear from you.

Yours Sincerely,
Sara

Sara Leo BSc, MD, FRCPC
Pediatric Clinical Immunology and Allergy, PGY-5
University of British Columbia
BC Children's Hospital
Email: sleo at cw.bc.ca
Pager: 410-1447

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