[CIS PIDD] 8mo old boy hypereosinophilia

[Hoernes Miriam]

Thank you very much for your input. We had already tested the T reg (CD4CD25CD127-) and they where elevated (absolute (473/ul) and relative values (38%)). In addition we have not found any autoantibodies (thyroid, pancreas). There are patients with IPEX-like Syndrome described in the literature with normal Treg numbers but not with elevated ones. Do you think we need further investigation to exclude these syndromes as well?
Thank you very much,

Miriam Hoernes

Dr. med. Miriam Hoernes
Ärztin Abteilung Immunologie/Allergologie
Jeffrey Modell Diagnostic Center for Primary Immunodeficiencies
Universitäts-Kinderspital Zürich
Steinwiesstrasse 75
CH-8032 Zürich
Tel.: +41 (0)44-266-7311
Fax: +41 (0)44-266-7914
e-mail: miriam.hoernes at kispi.uzh.ch






-----Original Message-----
From: Dr. Carsten Speckmann [mailto:carsten.speckmann at uniklinik-freiburg.de] 
Sent: Tuesday, September 18, 2012 5:00 PM
To: pagid at list.clinimmsoc.org; Hoernes Miriam
Subject: Re: [CIS PIDD] 8mo old boy hypereosinophilia

In addition to the mentioned differentials, you might also consider IPEX.
We have seen a large family with very variable phenotype, some patients 
had severe eczema during their 1st year of life and later onset of 
diarrhea and other problems (so that absence of gastrointestinal 
symptoms might not be sufficient to exclude this).

Carsten Speckmann

-- 
Dr. med. Carsten Speckmann
Facharzt
Zentrum fuer Kinderheilkunde und Jugendmedizin
Centrum fuer Chronische Immundefizienz - CCI
Universitaet Freiburg
Mathildenstr. 1
79106 Freiburg
Germany

phone: +49 (0)761-270 43010
mail: carsten.speckmann at uniklinik-freiburg.de
web: www.cci.uniklinik-freiburg.de


Am 18.09.12 16:24, schrieb Church, Joseph:

> Colleagues:

>

> Consider Wiscott-Aldrich - ? platelet size.

>

> Consider Omenn's or maternal GVHD - ? CD45RO/RA, T-cell receptor oligoclonality.

>

> Joe Church

> Children's Hospital Los Angeles

>

>

> -----Original Message-----

> From: pagid-bounces at list.clinimmsoc.org [mailto:pagid-bounces at list.clinimmsoc.org] On Behalf Of Reichenbach Janine

> Sent: Tuesday, September 18, 2012 6:57 AM

> To: pagid at list.clinimmsoc.org; 'pagid-bounces at list.clinimmsoc.org'

> Cc: Hoernes Miriam; Seger, Reinhard

> Subject: [CIS PIDD] 8mo old boy hypereosinophilia

>

>

>

>

>

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