[CIS PIDD] [cis-pidd] Patient question

[Rosenzweig, Sergio (NIH/NIAID) [E]]

Joe,
I know that this is not exactly what you was asking, but in order to reply to a reviewer I had to spend several hs looking for scientific evidence on how many infections normal kids (as the ones your pt is expecting to raise) develop per year. Here is what I found:  3-10 upper respiratory infections plus 1-4 otitis media per year, most of these viral infections (Henderson et al; NEJM 1982:306, 1377-1383; Chonmaitree et al; CID 2008:46, 815-823…fortunately, numbers fall within the range of what I knew on a non-scientific basis).
Sergio

Sergio D. Rosenzweig, MD, PhD
LHD, NIAID, NIH

From: <Church>, Joseph <JChurch at chla.usc.edu<mailto:JChurch at chla.usc.edu>>
Reply-To: CIS-PIDD <cis-pidd at lists.clinimmsoc.org<mailto:cis-pidd at lists.clinimmsoc.org>>
Date: Monday, March 4, 2013 9:57 PM
To: CIS-PIDD <cis-pidd at lists.clinimmsoc.org<mailto:cis-pidd at lists.clinimmsoc.org>>
Subject: [cis-pidd] Patient question

Colleagues:

I saw a young adult with CVID today.  He has just gotten engaged and asked the following:  when he has children how much of an infectious risk do they present to him?

I guess they present an increased risk for viral respiratory infections, but between appropriate immunizations of the kids and his excellent adherance with SCIG infusions he should be at no increased risk for life-threatening infections.

Any other thoughts?

Joe Church
Children's Hospital Los Angeles

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