[CIS PIDD] [cis-pidd] Subcutaneous Plaques following immunoglobbulin infusions

[Richard Wasserman]

I take care of a teenage ADA deficiency SCID patient who developed
subcutaneous nodules, indurated 2cm masses without overlying discoloration,
when he began treatment with the 20% product. They have been slow to
resolve. He is tolerating the low infusion site reaction 10% product
without problems.

Are you confident that these infusion were subcutaneous and not intradermal?
Richard Wasserman


On Wed, Jun 12, 2013 at 9:33 PM, Heimall, Jennifer
<heimallj at email.chop.edu>wrote:


>  I have an 18y/o patient with specific antibody deficiency who was

> treated with subcutaneous immunoglobulin replacement.  After about 10

> months, she developed painful nodules on the left flank.  We encouraged

> rotation of infusion sites and tried a change of product.

>

> Despite these changes and having been off of subcutaneous immunoglobulin

> for the last 2 months, she now has large (11cmx6cm), tender, firm plaques

> with overlying hyperpigmentation present on both sides of her lower

> abdomen.

>

> Has anyone else encountered this with patients on subcutaneous

> immunoglobulin?

>

>

>

>

>

>

> Jennifer Heimall, MD

> The Children's Hospital of Philadelphia

> Allergy/Immunology

> 3550 Market Street

> 3rd Floor

> Philadelphia, PA 19104

> phone: (267)426-9231

>

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-- 
Richard L. Wasserman, MD, PhD
DallasAllergyImmunology
7777 Forest Lane, Suite B-332
Dallas, Texas 75230
Office (972) 566-7788
Fax (972) 566-8837
Cell (214) 697-7211

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