[CIS PIDD] [cis-pidd] Yellow Fever Vaccine in sIgAD

[Church, Joseph]

Thanks, Dewton.  JC

From: Dewton Vasconcelos [mailto:dmvascon at usp.br]
Sent: Wednesday, June 19, 2013 10:40 AM
To: CIS-PIDD
Subject: Re: [cis-pidd] Yellow Fever Vaccine in sIgAD

Hi Joe, good afternoon

I would assume that if the patient has only IgA deficiency his/her cellular immunity is fine, therefore there is a low risk (similar to "healthy" individuals) of presenting a severe disease induced by YF vaccine.

In the inlands of Brazil the citizens are vaccinated by YF vaccine with very low adverse reactions.
One of my patients (homozygous for a IL-12RB1 mutation) was immunized with YF vaccine without adverse reaction (he only told me after being vaccinated).

Hope that could be useful.

Best regards,

Dewton

Dewton de Moraes Vasconcelos, MD, PhD
Primary Immunodeficiencies Outpatient Unit ADEE3003
Lab. of Medical Investigation Unit 56
University of São Paulo School of Medicine

Church, Joseph wrote:
Colleagues:

A 20+ year old patient is traveling to Africa and is recommended to receive Yellow Fever Vaccine.

She has selective IgA deficiency.  Assuming she does not have an antibody deficiency is there a contraindication to giving  her the YF vaccine?

Joe Church
Children's hospital Los Angeles

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