[CIS PIDD] [cis-pidd] 13+ yo with chronic thrush

[dmvascon at usp.br]

Hi Joe 

What about dectin-1 polymorphism? 
It seems that her clinical features are very mild and dectin-1 polymorphism is common at least in South Africa and mild. 
Where are her african relatives from? Does she know? 

Best, 

Dewton 

----- Mensagem original -----


> De: "Joseph Church" <JChurch at chla.usc.edu>

> Para: "CIS-PIDD" <cis-pidd at lists.clinimmsoc.org>

> Enviadas: Quinta-feira, 11 de Julho de 2013 20:50:10

> Assunto: [cis-pidd] 13+ yo with chronic thrush



> Colleagues:



> I have followed a 13+ year -old African American girl who reportedly

> developed thrush at 10 years of age.



> Growth and development have been normal. She does not routinely use

> inhaled steroids. Moderately severe posterior pharyngeal candidiasis

> (culture-documented) has been noted at several visits. Her only

> other physical finding is enlarged tonsils. She has had no other

> infections. She has no signs or symptoms of autoimmune disease. Her

> thrush is transiently responsive to anti-fungal therapy.



> HIV was negative. She has had mild lymphopenia that was reflected in

> borderline T, B and NK numbers, but mitogen and candida LPAs were

> present. She generated normal antibody responses to Pneumovax.



> What am I missing here?



> Joe Church

> Children’s Hospital Los Angeles



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