[CIS PIDD] [cis-pidd] 13+ yo with chronic thrush

[Church, Joseph]

Interesting thought Dewton.  I will see if patient is aware of her ancestry.  Most African-Americans are from central rather than south Africa.  JC

From: dmvascon at usp.br [mailto:dmvascon at usp.br]
Sent: Thursday, July 11, 2013 6:19 PM
To: CIS-PIDD
Subject: Re: [cis-pidd] 13+ yo with chronic thrush

Hi Joe

What about dectin-1 polymorphism?
It seems that her clinical features are very mild and dectin-1 polymorphism is common at least in South Africa and mild.
Where are her african relatives from? Does she know?

Best,

Dewton


________________________________
De: "Joseph Church" <JChurch at chla.usc.edu<mailto:JChurch at chla.usc.edu>>
Para: "CIS-PIDD" <cis-pidd at lists.clinimmsoc.org<mailto:cis-pidd at lists.clinimmsoc.org>>
Enviadas: Quinta-feira, 11 de Julho de 2013 20:50:10
Assunto: [cis-pidd] 13+ yo with chronic thrush
Colleagues:

I have followed a 13+ year-old African American girl who reportedly developed thrush at 10 years of age.

Growth and development have been normal.  She does not routinely use inhaled steroids.  Moderately severe posterior pharyngeal candidiasis (culture-documented) has been noted at several visits.  Her only other physical finding is enlarged tonsils.  She has had no other infections.  She has no signs or symptoms of autoimmune disease.  Her thrush is transiently responsive to anti-fungal therapy.

HIV was negative.  She has had mild lymphopenia that was reflected in borderline T, B and NK numbers, but mitogen and candida LPAs were present.  She generated normal antibody responses to Pneumovax.

What am I missing here?

Joe Church
Children’s Hospital Los Angeles







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