[CIS PIDD] [cis-pidd] C8 Deficiency

[Mark Tucker]

Hello,
 
I have a 31 y/o male patient who had recent admission for meningococcal
meningitis (serotype Y by PCR).  He has no history of recurrent
sinopulmonary infections and no history of previous meningitis.  He had been
vaccinated with meningococcal polysaccharide vaccine in 2010.  
 
On lab work up, during admission, he had low CH50 x 2, C3 and C4 were
normal.  Subsequent labs demonstrated low C8 level of 4.8mg/dl performed at
Quest Diagnostics.
 
He has since been immunized with pneumovax, prevnar and meningococcal
vaccines as has his immediate family members.  He has been receiving
prophylactic bicillin injections monthly. 
 
My questions are: 
1) Is further testing required in this individual concerning current
diagnosis of C8 def? 
2) Does anyone know of any common inheritance pattern?  Should children be
screened?
3) Should he continue prophylactic antibiotics?
 
Appreciate any thoughts/guidance.
 
V/R,
 
Mark Tucker, MD
CDR MC USN
NMCSD Allergy / Immunology 		 	   		  
---
The CIS-PIDD listserv is supported by the Clinical Immunology Society
The science & practice of human immunology

P: +1.414.224.8095
E: info at clinimmsoc.org

Not a member of CIS? Please visit www.clinimmsoc.org to join!

You are currently subscribed to cis-pidd as: pagid at list.clinimmsoc.org.
To unsubscribe click here: http://lm.clinimmsoc.org/u?id=183939985.3ea13d40a15475ac00ebbd9cd8a37d6d&n=T&l=cis-pidd&o=43647756
or send a blank email to leave-43647756-183939985.3ea13d40a15475ac00ebbd9cd8a37d6d at lists.clinimmsoc.org
-------------- next part --------------
An HTML attachment was scrubbed...
URL: <http://seven.pairlist.net/pipermail/pagid/attachments/20130730/3330cdf6/attachment-0001.htm>