[CIS PIDD] Post IVIG and neutropenia

[Santhosh Kumar/FS/VCU]

Hi everyone,

I have been following an interesting patient for almost a year. He has a 
hx of Hodgkin's lymphoma which is now in remission s/p Rituximab therapy . 
He was diagnosed with CVID and started on IVIG a year ago. He has baseline 
low WBC (2000-3000), neutrophil (1200-1500)  and lymphocyte count 
(600-1200) but drops even lower post IVIG. His wbc count drops to 1400 and 
his neutrophil count to 600 although his lymphocyte count stays the same. 
He has negative anti-neutrophil antibody. He also has low platelet counts 
98000-102000 but this does not seem to be affected by IVIG infusions. He 
has no symptoms associated with these low counts and I am currently trying 
to see how it takes before the levels come back to baseline. Today is day 
4 post IVIG and he continues to drop his WBC and Neutrophil counts. My 
question to the group:

1. Has anyone seen similar problem with IVIG
2. Is there a benefit in switching him to SQIG


Thank you,

Santhosh Kumar, MD
Assistant Professor,
Allergy & Immunology
MCV/VCU
Ph:804-628-1605
Fax-804-828-1751
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