[CIS PIDD] [cis-pidd] severe molluscum/ CMC

[Sokolic, Robert (NIH/NHGRI) [E]]

My best luck with molluscum in WAS has been with destructive methods – curretage or silver nitrate. Might be difficult depending on extent of lesions.


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From: Blachy Davila-Saldana <davilasa at ohsu.edu<mailto:davilasa at ohsu.edu>>
Reply-To: CIS-PIDD <cis-pidd at lists.clinimmsoc.org<mailto:cis-pidd at lists.clinimmsoc.org>>
Date: Thursday, October 24, 2013 7:07 AM
To: CIS-PIDD <cis-pidd at lists.clinimmsoc.org<mailto:cis-pidd at lists.clinimmsoc.org>>
Subject: [cis-pidd] severe molluscum/ CMC

Hello all;

I'd to hear your thoughts regarding a patient. This is a 20 month old female, only child to non-consanguineous parents, who has had severe eczematous dermatitis since around 4 weeks of age, not responsive to any treatment by dermatology.  She has required a previous hospital admission for wound consult management due to the severity, also had several episodes of suprainfection with Staph species, mostly MSSA.  Additionally, she developed molluscum contagiosum which has become widespread as well.  She has a history of reactive airway disease and frequent URI’s, but no documented pneumonias, abscesses or ear infections.  No severe thrush or fungal skin issues by history.

On exam, she is 50th percentile for both height and weight.  The dermatitis is severe and covers forearms, axillae, diaper area and legs.  Her molluscum covers her upper trunk and all extremities.  She has mild to moderate developmental delay.  Even with her severe rash, I only felt a couple small nodes on her occipital area, and none elsewhere.  She has dysplastic nails, mainly on her lower extremities.  Her hair is short and sparse.

Labs:
WBC 19.2, with ANC 5400, ALC 10000 and 1300 eos
Hgb 13.8
Plt 422

CMP normal, including normal albumin (3.6), glucose (90) and calcium (10.3)

IgG 265
IgA 65
IgM <10
IgE 28

Lymphocyte subsets:
- Normal total numbers of T cells and B cells
- Slightly decreased NK cells  (177.2 cells/ul)
- Slightly increased polyclonal CD5 positive B cells
- No monoclonal B cell population
- Naïve B cells 89.2%
- Non-switched, marginal zone like memory B cells 9%
- swiched memory B cells 0.7%

Mitogen proliferation studies:
Absent Lymphocyte responses to Candida
Low-normal Lymphocyte responses to Tetanus
Low-normal Lymphocyte responses to PHA.
Normal Lymphocyte responses to Con A.
Normal Lymphocyte responses to Pokeweed Mitogen.

HIV non-reactive

Antibodies:
Tetanus 0.1 (0.1 considered protective in this lab)
Diphteria 0.0
HiB 0.1 (1 or above considered protective)


She has been given another vaccine challenge and we will retest titers.  DOCK8 deficiency evaluation is in process.

A fungal culture from her nails grew yeast, only identified as NOT C. Albicans.  She was placed on fluconazole as well as aldara by dermatology, after a cantharone trial, but her molluscum continues to spread and is worsening.  As next treatment, and before we knew these results, she had two intralesional candida antigen injections, with no improvement (and no skin reaction, at all).

I know treatment of her skin will be challenging, but I was wondering how others have treated severe molluscum in this setting.  Additionally, I wondered of further testing.  Would you proceed with testing for CMC?  Should we consider screening further for endocrinopathies, even though her labs are normal?

Your thoughts are appreciated.

Blachy

Blachy J. Dávila Saldaña
PGY-7
Pediatric Hematology-Oncology Fellow
Mail Code CDRCP
3181 SW Sam Jackson Park Road
Portland OR 97231


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