[CIS PIDD] [cis-pidd] Unusual SCID Screen Work up

[Richard Wasserman]

I have been evaluating this now four month old Hispanic female with
repeatedly positive low/very low TRECs on Texas SCID screen. She was the
term product of a non-consangunious pregnancy. She has done well with one
mild URI. She is currently on prophylaxis with TMP/SMX. Her lab studies, in
date order are below:

*DOB: 130705*



*130726*

ALC 1814



*130730*

ALC 1800

PHA 47 (nl >66)



*130809*

ALC 1800

CD3 abs 718, CD4 abs 538, CD8 abs 178, CD19 abs 544 CD56/16  abs 482

PHA 24 (nl >66)

IgM 10 mg/dL



*130813*

Adenosine Deaminase normal



*130821*

ALC 2200

PHA 111 (nl >66)

IgM 10mg/dL



*130904*

CD3 abs 957, CD4 abs 682, CD8 abs 267, CD19 abs 1059 CD56/16  abs 795



*130924*

CD3 abs 506, CD4 abs 373, CD8 abs 128, CD19 abs 698 CD56/16  abs 533

IgM 63mg/dL



*131001*

CD3 Abs 673, CD3CD4 abs 522, CD3CD8 abs 140

CD3+ 27%, CD4+ (of CD3) 68%, CD8+ (of CD3) 27%

CD4 Naïve 62%, CD4 Memory 38%

CD8 Naïve 90%, CD8 Memory 10%



CD4 Naïve CD31+ 78%, CD4 Naïve CD31- 21%, CD4 memory Tcm 18%, CD4 Memory
Tem 22%, TEMRA 0.1%



CD8 Memory Tcm NR%, CD8 Memory Tem NR%, TEMRA 0.1%



*131029*

TREC 3925 (nl >4168)

ALC 1524

CD3 Abs 673, CD3CD4 abs 522, CD3CD8 abs 140

CD3+ 41%, CD4+ (of CD3) 76%, CD8+ (of CD3) 21%

CD4 Naïve 56%, CD4 Memory 44%

CD8 Naïve 85%, CD8 Memory 14%



CD4 Naïve CD31+ 72%, CD4 Naïve CD31- 28%, CD4 memory Tcm 22%, CD4 Memory
Tem 24%, TEMRA 0%



CD8 Memory Tcm 3.3%, CD8 Memory Tem 24.9%, TEMRA 0.2%


Any suggestions regarding further evaluation would be appreciated.

Thanks,

Richard Wasserman

-- 
Richard L. Wasserman, MD, PhD
DallasAllergyImmunology
7777 Forest Lane, Suite B-332
Dallas, Texas 75230
Office (972) 566-7788
Fax (972) 566-8837
Cell (214) 697-7211

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