[CIS PIDD] abnormal placenta and fetal loss

[Nancy Kingston]

We encountered a patient on the MFM (maternal fetal medicine) service who lost a pregnancy in the mid-second trimester.  The only findings were fetal growth restriction and chronic histiocytic intervillositis.  Has anyone in the immunology community studied such cases?   From a histologic perspective it appears to be a maternal immune response to paternal antigen(s) expressed by the fetus (placenta) or perhaps some other mechanism for a maternal inflammatory response.
 
Appreciate your help with this question.  Thanks much.
 
Nancy Wasserbauer, DO
Division of Allergy and Immunology
Akron Children's Hospital
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