[CIS PIDD] [cis-pidd] Posaconazole in CGD patients

[Boyce, Thomas G., M.D.]

I think either is fine.  I don't think itraconazole is  inferior.  Both have good aspergillus activity.  We have more experience with it in children, it probably has fewer side effects than posaconazole, and posa has more erratic absorption and a shorter half-life.

From: Pere Soler Palacin [mailto:psoler at vhebron.net]
Sent: Tuesday, March 18, 2014 10:59 AM
To: CIS-PIDD
Cc: Mai Figueras
Subject: [cis-pidd] Posaconazole in CGD patients


Dear all, we are currently considering if primary antifungal prophylaxis should be universally switched from itra to posaconazole in CGD patients. As far as I know, there's no consensus about it but it seems logical to me than we should offfer the best choice to these patients who are at high risk of IFI during their entire life, even more if time on primary prophylaxis is currently shorter since most of them are transplanted.



Any thoughts or experiences?



P.



Pere Soler Palacín, MD, PhD.
Pediatric Infectious Diseases and Immunodeficiencies Unit. Hospital Universitari Vall d'Hebron.
Assistant Professor. Universitat Autònoma de Barcelona.
Passeig de la Vall d'Hebron 119-129.
08035 Barcelona. Spain.
Tel: 0034934893140. Fax: 0034934893039.
E-mail: psoler at vhebron.net<mailto:psoler at vhebron.net>; 34660psp at comb.cat<mailto:34660psp at comb.cat>. Web: www.upiip.com<http://www.upiip.com/>.



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