[CIS PIDD] [cis-pidd] HLH gene testing

[Risma, Kimberly]

Thanks, Dr. Verbsky, see below for information on the panel you mentioned, Kim

Dr Kahn Preece:

We are about to start offering the HLH panel testing including all HLH/XLP associate genes later this week. 
Please check on this website on Thursday, it should have all  the necessary information to ordering this new test.

Thanks and let me know if you have any questions.

Kejian Zhang MD, MBA
Associate Professor of Clinical Pediatrics 
Director, Molecular Genetics Laboratory 
Division of Human Genetics Children's Hospital Medical Center 
University of Cincinnati, College of medicine

Phone: (513) 636-1867
Fax: (513) 636-2261
Pager: 303-8317
Email: kejian.zhang at cchmc.org
Website: http://www.cincinnatichildrens.org/service/d/diagnostic-labs/molecular-genetics/default/




-----Original Message-----
From: Verbsky, James [mailto:jverbsky at mcw.edu] 
Sent: Sunday, May 11, 2014 11:37 PM
To: CIS-PIDD
Subject: Re: [cis-pidd] HLH gene testing

Cincinnati has an extensive panel. You might contact Dr Risma or Dr Filopovich for details. Their clinical lab

http://www.cincinnatichildrens.org/service/h/hlh/clinical/test/

Best

James Verbsky


Sent from my iPad

On May 11, 2014, at 4:17 PM, "Kahn Preece (ADHB)" <KahnP at adhb.govt.nz<mailto:KahnP at adhb.govt.nz>> wrote:

Hi all,

I am Pediatric Clinical Immunologist in Auckland, New Zealand. We recently had a 12month old male patient transferred from Tonga (a small collection of pacific islands to the north). His was a tragic story.

Two weeks preceding transfer he lost a 6 year old brother to a rapid systemic illness that was undiagnosed. His male monozygotic twin then became ill and over the course of 3-4 days became severely unwell and died of overwhelming hypotension and renal failure. Again no diagnosis was made and limited clinical history for the two boys on the islands. Local epidemiology had a recent increase in chikungunya infections and this was initially thought to be implicated, despite the much more severe outcome than would be expected.

On transfer he was febrile but clinically had only a mild illness. He rapidly deteriorated and died day 4 of admission. He had a diagnosis of HLH made on day three of admission after unrelenting fever, hepatitis, Hyperferritinemia (>50 000), hypertriglyceridemia, cytopenia and organomegally. No biopsy was taken (BM or liver). He was commenced on HLH2004 but died soon after. EBV load on whole blood was 3.2 log copies per ml (1900 IU/ml) 24hrs prior to his ultimate demise. Other extensive viral serology, including Chikungunya and dengue, was negative. There was no dysgammaglobulinaemia and his history up to that point was infection free. There was no other relevant family history and no divulged consanguinity.

We are trying to minimize the cost of genetic analysis for this family who are not covered by the NZ public health care system. I am therefore enquiring about the possibility of a genetic "panel" for hereditary HLH, including obviously XLP1 and 2 but also the FHL1-5. Is this something anyone is aware of that is run commercially? If so what is the cost and turnaround time? Also, as a side note, is it possible to have an episode of EBV triggered HLH with XLP and have such a low viral load?

Thanks in advance for your time.


Dr Kahn Preece
Paediatric Immunologist
Starship Children's Health
kahnp at adhb.govt.nz<mailto:kahnp at adhb.govt.nz>


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