[CIS PIDD] [cis-pidd] 14yo with recurrent Staph aureus sepsis

[Nima Parvaneh]

Dear Joe, 

Did you check the anti-IL6 autoantibodies. as the patient had a normal
past medical history during the early years, he most probably have an
acquired condition. Please see the following ref: 

Recurrent STAPHYLOCOCCAL cellulitis and subcutaneous abscesses in a
child with autoantibodies against IL-6. [5] J Immunol. 2008 Jan
1;180(1):647-54 

Yours, 

nima. 

On 2014-06-03 17:59, Church, Joseph wrote: 

> His skin is normal, no eczema, fungal infections, warts etc. IgE is pending; no eosinophilia. JC 
> 
> FROM: Heimall, Jennifer [mailto:heimallj at email.chop.edu] 
> SENT: Monday, June 02, 2014 8:17 PM
> TO: CIS-PIDD
> SUBJECT: Re: [cis-pidd] 14yo with recurrent Staph aureus sepsis 
> 
> Any other history of eczema, fungal infection or warts? Any elevation in ige or eosinophilia? I am thinking of perhaps a DOCk8- some were not too sick until their teens. 
> 
> Jen
> 
> Sent from my iPhone 
> 
> On Jun 2, 2014, at 7:56 PM, "Church, Joseph" <JChurch at chla.usc.edu> wrote: 
> 
>> Colleagues: 
>> 
>> I was asked to evaluate a previously very healthy 14yo boy who experienced the following: 
>> 
>> · 2012 Cellulitis (likely Staph) after an insect bite 
>> 
>> · 2013 Staph aureus, methicillin sensitive, septic shock after minor skin trauma and possible local infection 
>> 
>> · 2014 Staph aureus, methicillin sensitive, sepsis. 
>> 
>> He has a past history of a 4mm VSD, but echocardiography on two occasions failed to reveal a focus of infection. 
>> 
>> Neutrophil counts were repeatedly normal. 
>> 
>> Physical exam is normal except for a III/VI ejection murmur. 
>> 
>> I have never read that CGD or LAD presents like this. I plan to suggest a closer look at his heart valves. Any other suggestions? 
>> 
>> Joe Church 
>> 
>> Children's Hospital Los Angeles 
>> 
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-- 

Nima Parvaneh, MD.
Assistant Professor
Department of Pediatrics
Division of Allergy and Clinical Immunology
Tehran University of Medical Sciences
62 Gharib St, 14194 Tehran, Iran
Tel: +98-21-66920982
Fax: +98-21-66923054
Email: nparvaneh at tums.ac.ir
 

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