[CIS PIDD] [cis-pidd] Severe aphthous ulcers in an adolescent with CVID

[Bodo Grimbacher]

unlikely, but nobody has mentioned so far: HSV has been excluded by
special virology swab?
also very rare: STAT1 GOF mutations can do oral ulcers and hypogammaŠ
Best, Bodo

****************************************
Univ.-Prof. Dr. med. B. Grimbacher
Scientific Director
CCI-Center for Chronic Immunodeficiency
UNIVERSITÄTSKLINIKUM FREIBURG
Tel.: 0761 270-77731  Fax: -77744
Engesserstraße 4, 79108 Freiburg
bodo.grimbacher at uniklinik-freiburg.de
http://www.uniklinik-freiburg.de/cci









Am 05.06.14 08:21 schrieb "Jane Peake" unter <j.peake at uq.edu.au>:

>Hi all
>I have a young girl with CVID who has been plagued with severe disabling
>aphthous ulcers for many years. Since starting on IVIg her infectious
>problems have largely resolved and her ulcers are better but they are
>still problematic. She
> gets them on her tongue, buccal mucosa and roof of the mouth and when
>she has them she finds eating and speech very difficult. Episodes are
>intermittent but she rarely goes more than a couple of weeks without a
>severe episode. She has had a couple of episodes
> of labial lesions but since starting doxycycline (on the advice of the
>gynaecologists) she has only had one episode when they had run out of the
>doxycycline. We have tried a variety of topical treatments ­ local
>anaesthetics and steroids. She responds well
> to oral steroids but these cannot be used regularly. Does anybody have
>any other ideas in this setting?
>Thanks for any suggestions
>Cheers Jane
> 
>Dr Jane Peake
>Paediatric Immunologist and Allergist
>Senior Lecturer
>University of Queensland
>level 3 Foundation Building
>Royal Children's Hospital
>Herston Rd, Herston QLD 4029
> 
> 
>
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