[CIS PIDD] [cis-pidd] Hypogammaglobulinemia and light chain deposition in kidneys

[Anastasiya Ashurova]

We would like to elicit your opinion on a case we saw in our office.  An
adult patient presented to our office for immune workup in the setting of
frequent upper respiratory infections,  IgG of 679mg/dL, non protective
diphtheria and pneumococcal titers and most notably CD19 of 1573.  She was
subsequently vaccinated with Pneumovax 23 and Td and returned two months
later with a large mass over the site of her Td vaccination (left arm)
and diffuse
lymphadenopathy.  Biopsy of both an axillary lymph node and mass was
positive for small lymphocytic lymphoma/CLL.

We now have a patient in our office with CLL, CD19 of 13000 in need of
Pneumovax.  What has been your experience in vaccination patients with
elevated B cell counts? Has anyone observed “unmasking” or worsening of a
lymphoproliferative disorder after immunization?


Thank you,

 Anastasiya Kleva

Fellow, Steven & Alexandra Cohen Children’s Medical Center.

---
The CIS-PIDD listserv is supported by the Clinical Immunology Society
The science & practice of human immunology

P: +1.414.224.8095
E: info at clinimmsoc.org

Not a member of CIS? Please visit www.clinimmsoc.org to join!

You are currently subscribed to cis-pidd as: pagid at list.clinimmsoc.org.
To unsubscribe click here: http://lm.clinimmsoc.org/u?id=183939985.3ea13d40a15475ac00ebbd9cd8a37d6d&n=T&l=cis-pidd&o=45107266
or send a blank email to leave-45107266-183939985.3ea13d40a15475ac00ebbd9cd8a37d6d at lists.clinimmsoc.org
-------------- next part --------------
An HTML attachment was scrubbed...
URL: <http://seven.pairlist.net/pipermail/pagid/attachments/20140702/8a796c7b/attachment-0001.html>