[CIS PIDD] [cis-pidd] Chronic Norovirus Infection

Tue Sep 23 08:26:22 EDT 2014

Fabio and I had a patient with ADA-SCID who had gene therapy without clinical benefit. She developed acute norovirus gastroenteritis that became chronic. We treated her with oral gamunex. She became asymptoamtic, but continued with norovirus carriage for 2-3 years, then resolved. Prior to resolution, attempts to remove gamunex led to recurrent diarrhea.

R

________________________________
From: Pere Soler Palacin [psoler at vhebron.net]
Sent: Tuesday, September 23, 2014 7:18 AM
To: CIS-PIDD
Subject: Re: [cis-pidd] Chronic Norovirus Infection

Dear all, we had a patient with RAG-1 deficiency + URD-SCT with persistent viral excretion in feces. However, symptoms did not persist and the patient remained asymptomatic.
Hope it's useful

P.

Pere Soler Palacín, MD, PhD.
Pediatric Infectious Diseases and Immunodeficiencies Unit. Hospital Universitari Vall d'Hebron.
Assistant Professor. Universitat Autònoma de Barcelona.
Passeig de la Vall d'Hebron 119-129.
08035 Barcelona. Spain.
Tel: 0034934893140. Fax: 0034934893039.
E-mail: psoler at vhebron.net<mailto:psoler at vhebron.net>; 34660psp at comb.cat<mailto:34660psp at comb.cat>. Web: www.upiip.com<http://www.upiip.com/>.

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________________________________
De: "David Edgar" <david.edgar at belfasttrust.hscni.net>
Per: "CIS-PIDD" <cis-pidd at lists.clinimmsoc.org>
Enviats: Dimarts, 23 de Setembre 2014 11:17:39
Assumpte: RE:[cis-pidd] Chronic Norovirus Infection

Hi Joe
I have a 16 year old boy with XLA and chronic norovirus (c 12 years now), causing significant debility and unresponsive to many therapeutic approaches.
David

Dr J. David Edgar
Consultant Immunologist & Senior Lecturer
Regional immunology Service
The Royal Hospitals
Belfast BT12 6BN

Ph: +442890630003
Fax: +442890635482

From: Church, Joseph [mailto:JChurch at chla.usc.edu]
Sent: 23 September 2014 00:37
To: CIS-PIDD
Subject: [cis-pidd] Chronic Norovirus Infection

Colleagues:

I am trying to get some idea of the extent of chronic norovirus infection in patients with primary or acquired immunodeficiency.

I would very much appreciate your letting me know how many such patients you follow and their underlying immune deficiencies.

Thank you for your help.

Joe Church
Children’s Hospital Los Angeles

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