[CIS PIDD] [cis-pidd] IVIG/ScIg for Complement deficiency?

[Church, Joseph]

This makes no sense to me.  The patients' problem is not the inability to make antibodies, it is the inability to use complement that is activated by the classical pathway (or lectin pathway) regardless of the source of antibodies.

Joe Church
Children's Hospital Los Angeles

From: Jason Raasch [mailto:jraasch at midwestimmunology.com]
Sent: Monday, April 13, 2015 1:31 PM
To: CIS-PIDD
Subject: [cis-pidd] IVIG/ScIg for Complement deficiency?

Hello everyone.

I have heard of some practitioners in our region using IVIG as sole management for isolated C2 deficiency in infants/children (i.e. instead of prophylactic antibiotics, immunizations for encapsulated organisms, etc.).  The feeling is long-term use of prophylactic antibiotics in these cases is irresponsible.

I will be honest and admit I have not heard of this before or found much in the literature.  What am I missing here?

I would appreciate any comments.

Regards,

Jason


Jason Raasch, MD

Midwest Immunology Clinic
15700 37th Ave N, Ste 110
Plymouth, MN 55446

TEL: (763) 577-0008
FAX: (763) 577-0192







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