[CIS PIDD] [cis-pidd] HHV6 meningoencephalitis

[Boyce, Thomas G., M.D.]

Dear Maite,

It is very difficult to know if HHV-6 is the cause of encephalitis as asymptomatic reactivation is common. Primary infection occurs before age 2 in the vast majority of children. I would consider testing for the various causes of autoimmune encephalopathy and other progressive neurological conditions.

Personally, I would not hesitate to give live vaccines to a child with normal T cell counts and function.

Tom Boyce
Peds ID
Mayo Clinic



On Jun 19, 2015, at 4:55 PM, Maite de la Morena <Maite.delaMorena at UTSouthwestern.edu<mailto:Maite.delaMorena at UTSouthwestern.edu>> wrote:

Dear all
I have seen a 4 yof who developed HHV6 meningoencephalitis at age 3 and now has seizures, now severe developmental delay.
Had been achieving milestones appropriately until then

Negative serologies for CMV, EBV, HSV but + IgG for HHV6 (Negative IgM),
serum Igs and specific response to vaccines normal, Normal flow and normal mitogens and antigens .
Normal perforin, NK function and CTLs and TLR signaling ( ARUP )

She has not received MMR or varicella. I am hesitant to give these.
Would appreciate your comments
Thank you
Maite

Maite de la Morena, MD
Professor of Pediatrics  and Internal Medicine
Division of Allergy and Immunology
University of Texas Southwestern Medical Center in Dallas
5323 Harry HInes Blvd
Dallas, Texas 75390-9063
Phone 214 456-5161
Fax: 214 456-8317
Email: maite.delamorena at utsouthwestern.edu<mailto:maite.delamorena at utsouthwestern.edu>


________________________________

UT Southwestern


Medical Center



The future of medicine, today.


---

You are currently subscribed to cis-pidd as: boyce.thomas at mayo.edu<mailto:boyce.thomas at mayo.edu>.

To unsubscribe click here: http://cts.dundee.net/u?id=96396433.55ecf5652c5a72d7e01ad4fcc04d3599&n=T&l=cis-pidd&o=2921385

(It may be necessary to cut and paste the above URL if the line is broken)

or send a blank email to leave-2921385-96396433.55ecf5652c5a72d7e01ad4fcc04d3599 at lyris.dundee.net<mailto:leave-2921385-96396433.55ecf5652c5a72d7e01ad4fcc04d3599 at lyris.dundee.net>

---
You are currently subscribed to cis-pidd as: pagid at list.clinimmsoc.org.
To unsubscribe click here: http://cts.dundee.net/u?id=96396833.5a9591ccd1e327fe6bc4d1543298c482&n=T&l=cis-pidd&o=2922423
or send a blank email to leave-2922423-96396833.5a9591ccd1e327fe6bc4d1543298c482 at lyris.dundee.net
-------------- next part --------------
An HTML attachment was scrubbed...
URL: <https://pairlist7.pair.net/pipermail/pagid/attachments/20150620/a974ba06/attachment-0001.html>