[CIS PIDD] [cis-pidd] 42yo M, CVID ?reaction to Hizentra

[Church, Joseph]

Thank you, Isabelle.  Your comment about excipients and excitatory channels in the CNS was most interesting.  Do you have a reference or two regarding this?  JC

From: Isabelle Meyts [mailto:isabelle.meyts at uzleuven.be]
Sent: Tuesday, July 07, 2015 10:39 PM
To: CIS-PIDD
Subject: Re: [cis-pidd] 42yo M, CVID ?reaction to Hizentra

Dear Joseph,

I have had this experience with several Ig products (scig and ivig) in children.
Kids transformed from quiet school kids to angry and almost aggressively behaving children.
I have initially attributed this to the excipiens as most play a role in excitatory channels in the CNS. Trying to split the doses has helped but of course this means more frequent injections.
When i was trying to objectivate this parental description a few years ago, i didn't come accross any literature data.

Best wishes

Isabelle Meyts
UZ Leuven, Belgium





Op 7-jul.-2015 om 16:52 heeft "Church, Joseph" <JChurch at chla.usc.edu<mailto:JChurch at chla.usc.edu>> het volgende geschreven:
Colleagues:

I follow a 42yo M with CVID.  He had been very stable on weekly Hizentra infusions.

Over the past several infusions he has gotten very "tense" the day after the infusion.  This fades by the day or two afterwards.  He has experienced anxiety in the past but Ativan has not helped his current symptoms, and he does not believe the tension is the same feeling as his anxiety.

Any experience with this type of reaction?  Any suggestions for prevention?

Thanks.

Joe Church
Children's Hospital Los Angeles







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