[CIS PIDD] [cis-pidd] poor antigen responsiveness

[Richard Wasserman]

Several years ago I picked up a child who had been evaluated by a
non-immunologist at age two. Immunoglobulins and T cell numbers were
marginal. He was maintained on immunoglobulin, anti-bacterial and
anti-fungal prophylaxis with only a modest history of infections. I
discontinued all treatments over a year and he has done well for the
subsequent five years with no significant infections. Simple URIs do not
have a prolonged recovery.

Three years ago immunoglobulins and vaccine responses were normal as were
CD 3,4,8,16/56 and 19. Mitogen responses were normal. There was no response
in vitro to candida or tetanus. Reevaluation (without remeasuring specific
antibodies) was the same with normal lymphocyte numbers and mitogen
responses but no detectable response to tetanus or candida.

I plan to just follow him and reevaluate in a few years. Any other
suggestions?

Richard Wasserman
Dallas

-- 
Richard L. Wasserman, MD, PhD
Allergy Partners of North Texas
7777 Forest Lane, Suite B-332
Dallas, Texas 75230
Office (972) 566-7788
Fax (972) 566-8837
Cell (214) 697-7211

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