[CIS PIDD] [cis-pidd] 2 children with elevated IgM

[CIS-PIDD]

Colleagues:

We are seeing 2 sisters, 2 and 4 years of age, who have histories of minor respiratory tract infections.  There is no family history of immune deficiency or dysfunction.  Physical examinations are normal, and growth and development are normal.

Labs demonstrated normal IgG and IgA levels and normal antibody responses to routine immunizations.  Both children had IgM levels in the 1,500mg/dL range (~10 x upper limit of normal).

I am at a loss to come up with a cause for their "hyper IgM."

Your thoughts would be appreciated.

Joe Church
Children's Hospital Los Angeles




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