[CIS PIDD] [cis-pidd] 2 children with elevated IgM

[CIS-PIDD]

Ataxia teleangiectasia ? would recommend to check AFP.
Best regards,
Markus Seidel
Graz, Austria

Am 30.09.2015 um 20:10 schrieb CIS-PIDD <cis-pidd at lists.clinimmsoc.org<mailto:cis-pidd at lists.clinimmsoc.org>>:

Assuming that they are both healthy – could they be making monomeric IgM?

Anthony

From: CIS-PIDD [mailto:cis-pidd at lists.clinimmsoc.org]
Sent: Wednesday, September 30, 2015 1:59 PM
To: CIS-PIDD <cis-pidd at lyris.dundee.net<mailto:cis-pidd at lyris.dundee.net>>
Subject: [cis-pidd] 2 children with elevated IgM

Colleagues:

We are seeing 2 sisters, 2 and 4 years of age, who have histories of minor respiratory tract infections.  There is no family history of immune deficiency or dysfunction.  Physical examinations are normal, and growth and development are normal.

Labs demonstrated normal IgG and IgA levels and normal antibody responses to routine immunizations.  Both children had IgM levels in the 1,500mg/dL range (~10 x upper limit of normal).

I am at a loss to come up with a cause for their “hyper IgM.”

Your thoughts would be appreciated.

Joe Church
Children’s Hospital Los Angeles



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