[CIS PIDD] [cis-pidd] 2 children with elevated IgM

[CIS-PIDD]

Hi Joe,
 
Any issues with EBV or evidence of splenomegaly?  We had a young lady
with some relatively mild ear infections and sinus infections (although
she also had CD4 lymphopenia) with a AD gain of function muation in
PI3KCD.  Just a thought...
 
Take care,
 
Dave
 
David Buchbinder, MD
CHOC Children's Hospital  

>>> "CIS-PIDD" <cis-pidd at lists.clinimmsoc.org> 9/30/2015 10:58 AM >>>

Colleagues:
 
We are seeing 2 sisters, 2 and 4 years of age, who have histories of
minor respiratory tract infections.  There is no family history of
immune deficiency or dysfunction.  Physical examinations are normal, and
growth and development are normal.
 
Labs demonstrated normal IgG and IgA levels and normal antibody
responses to routine immunizations.  Both children had IgM levels in the
1,500mg/dL range (~10 x upper limit of normal).
 
I am at a loss to come up with a cause for their “hyper IgM.”  
 
Your thoughts would be appreciated.
 
Joe Church
Children’s Hospital Los Angeles
 
 


---------------------------------------------------------------------
CONFIDENTIALITY NOTICE: This e-mail message, including any attachments,

is for the sole use of the intended recipient(s) and may contain
confidential
or legally privileged information. Any unauthorized review, use,
disclosure
or distribution is prohibited. If you are not the intended recipient,
please
contact the sender by reply e-mail and destroy all copies of this
original message. 

---------------------------------------------------------------------

---
You are currently subscribed to cis-pidd as: dbuchbinder at choc.org.
To unsubscribe click here:
http://cts.dundee.net/u?id=96396481.905e75689f86143242a7fcc04e69bfcb&n=T&l=cis-pidd&o=3170305
(It may be necessary to cut and paste the above URL if the line is
broken)
or send a blank email to
leave-3170305-96396481.905e75689f86143242a7fcc04e69bfcb at lyris.dundee.net

CHOCLX-MGSM made the following annotations
---------------------------------------------------------------------
Wed Sep 30 2015 11:34:01 

This email message and any files transmitted are sent with confidentiality in mind and contain privileged or copyright information. You must not present this message to another party without gaining permission from the sender.  If you are not the intended recipient you must not copy, distribute or use this email or the information contained in it for any purpose other than to notify Children's Hospital of Orange County.  Any views expressed in this message are those of the sender, except where the sender specifically states them to be the views of Children's Hospital of Orange County. If you have received this message in error, please notify the sender immediately, and delete this email from your system. We do not guarantee that this material is free from viruses or any other defects although due care has been taken to minimize the risk.

---------------------------------------------------------------------


---
You are currently subscribed to cis-pidd as: pagid at list.clinimmsoc.org.
To unsubscribe click here: http://cts.dundee.net/u?id=96396833.5a9591ccd1e327fe6bc4d1543298c482&n=T&l=cis-pidd&o=3170435
or send a blank email to leave-3170435-96396833.5a9591ccd1e327fe6bc4d1543298c482 at lyris.dundee.net
-------------- next part --------------
An HTML attachment was scrubbed...
URL: <https://pairlist7.pair.net/pipermail/pagid/attachments/20150930/ae760c76/attachment-0001.html>