[CIS PIDD] [cis-pidd] Recurrent HSV2 myelitis?

[CIS-PIDD]

Thanks Philipp.

Sure we have! ;=)

Thinking of the analogy:  NMDARAb+ encephalitis after HSV1 HSE  is a known entity, but it is clinically rather different from HSE (and HSE recurrences)  and AFAIK never causes HSV-PCR to revert back to positive.

Our lady had had repeated negative PCRs in between episodes, and both PCR (I think 5-6 times if my memory serves me correct) and MRI (twice) have repeatedly become also positive during a recurrence. Thus that it actually is HSV2 that is the culprit seems solid indeed. I would not seek an alternative dg thus. But we did belatedly (after NMDARAbs were discovered) check for these as well, I think at Josip Dalmau's/Philadelphia lab but might have been Stöcker's/Germany instead.

Mikko


oyl Mikko Seppänen
Harvinaissairauksien yksikkö (HAKE), HUS

Mikko Seppänen, MD, PhD, Associate professor
Specialist in Internal Medicine and Infectious Diseases
Chief, Rare Disease Center, Helsinki University Hospital (HUH)
Children's Hospital, P.O.Box 280
FI-00029 HUS
FINLAND
&
Senior Consultant (PIDD)
Adult Immunodeficiency Unit
Inflammation Center, HUH

phone +358 9 47180201
GSM +358 50 4279606
fax +358 9 47174703




Lähettäjä: CIS-PIDD [mailto:cis-pidd at lists.clinimmsoc.org]
Lähetetty: 27. lokakuuta 2015 14:13
Vastaanottaja: CIS-PIDD
Aihe: [MARKETING]Re: [cis-pidd] Recurrent HSV2 myelitis?

Have you looked for NMDAR antibodies?
Regards
Philipp


Dr. Philipp Henneke
Professor
Head Ped. Infectious Dis & Rheumatology
UNIVERSITY MEDICAL CENTER FREIBURG
Center for Chronic Immundefiency (CCI)
Center for Pediatrics & Adolesc. Medicine
phone assist/ office + 49(0)761270 77640
mobil +49 (0)162 285 2481
fax +49 (0) 761 270 77600
Breisacherstr. 117-2.OG, 79106 Freiburg

Von: CIS-PIDD <cis-pidd at lists.clinimmsoc.org<mailto:cis-pidd at lists.clinimmsoc.org>>
Antworten an: CIS-PIDD <cis-pidd at lyris.dundee.net<mailto:cis-pidd at lyris.dundee.net>>
Datum: Dienstag, 27. Oktober 2015 12:51
An: CIS-PIDD <cis-pidd at lyris.dundee.net<mailto:cis-pidd at lyris.dundee.net>>
Betreff: [cis-pidd] Recurrent HSV2 myelitis?

Hi all!

has anyone ever seen a match for my probably ultra-rarest patient:

recurrent HSV2 myelitis (PCR repeatedly +, MRI +)?

Doing well on antiviral long term medication for years now. We have performed WES on her, no low hanging fruits there..

If you have a match and mutually beneficial research is of interest, please contact me?

Mikko


oyl Mikko Seppänen
Harvinaissairauksien yksikkö (HAKE), HUS

Mikko Seppänen, MD, PhD, Associate professor
Specialist in Internal Medicine and Infectious Diseases
Chief, Rare Disease Center, Helsinki University Hospital (HUH)
Children's Hospital, P.O.Box 280
FI-00029 HUS
FINLAND
&
Senior Consultant (PIDD)
Adult Immunodeficiency Unit
Inflammation Center, HUH

phone +358 9 47180201
GSM +358 50 4279606
fax +358 9 47174703


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