[CIS PIDD] [cis-pidd] Zoster vaccine in CVID

[CIS-PIDD]

So what do you think about giving the live Zoster vaccine to a "standard" CVID adult (low but + ab titre to H. zoster) as the person already harbors the natural wild type virus. This is different than giving it to a CVID child/youngster who has never had infection with H. zoster.

Yes, I know the package insert says

"Immunosuppression ZOSTAVAX is a live, attenuated varicella-zoster vaccine and administration may result in disseminated disease in individuals who are immunosuppressed or immunodeficient. Do not administer ZOSTAVAX to immunosuppressed or immunodeficient individuals including those with a history of primary or acquired immunodeficiency states, leukemia, lymphoma or other malignant neoplasms affecting the bone marrow or lymphatic system, AIDS or other clinical manifestations of infection with human immunodeficiency viruses, and those on immunosuppressive therapy" SOURCE: ZOSTAVAX PACKAGE INSERT

Andy Saxon, MD, Clinical Immunology/Allergy, UCLA

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