[CIS PIDD] [cis-pidd] CVID and lung adenocarcinoma

Thu Apr 7 15:45:56 EDT 2016

Thank you, Charlotte.  JC

From: CIS-PIDD [mailto:cis-pidd at lists.clinimmsoc.org]
Sent: Thursday, April 07, 2016 12:44 PM
To: CIS-PIDD
Subject: Re: [cis-pidd] CVID and lung adenocarcinoma

Sorry forgot to sign!

Charlotte

Charlotte Cunningham-Rundles, MD, PhD

Departments of Medicine and Pediatrics

The David S Gottesman Professor

The Immunology Institute

Mount Sinai School of Medicine

1425 Madison Avenue

New York, NY 10029

Phone: 212 659 9268

Fax: 212 987 5593

Email: Charlotte.Cunningham-Rundles at mssm.edu<mailto:Charlotte.Cunningham-Rundles at mssm.edu>

From: "cis-pidd at lists.clinimmsoc.org<mailto:cis-pidd at lists.clinimmsoc.org>" <cis-pidd at lists.clinimmsoc.org<mailto:cis-pidd at lists.clinimmsoc.org>>
Reply-To: CIS-PIDD <cis-pidd at lyris.dundee.net<mailto:cis-pidd at lyris.dundee.net>>
Date: Thursday, April 7, 2016 at 2:37 PM
To: CIS-PIDD <cis-pidd at lyris.dundee.net<mailto:cis-pidd at lyris.dundee.net>>
Subject: RE: [cis-pidd] CVID and lung adenocarcinoma

Thank you, but who responded?  JC

From: CIS-PIDD [mailto:cis-pidd at lists.clinimmsoc.org]
Sent: Thursday, April 07, 2016 8:45 AM
To: CIS-PIDD
Subject: Re: [cis-pidd] CVID and lung adenocarcinoma

we have had 2 lung cancers - both adenocarcinoma-

you might ask USIDNET how many have been observed. Not sure if we have smoking as a field.

On Apr 6, 2016, at 8:19 PM, CIS-PIDD <cis-pidd at lists.clinimmsoc.org<mailto:cis-pidd at lists.clinimmsoc.org>> wrote:

Colleagues:

I follow a 34yo man with CVID.  Because of a persistent cough and a CT suggestive of early interstitial disease, he had a VATS lung biopsy.  There were minimal interstitial changes, but an area of "atypical adenomatous hyperplasia (AAH)" was noted on pathology.  Apparently AAH may precede the development of adenocarcinoma.

Has anyone seen AAH or lung adenocarcinoma in a non-smoking adult with CVID?

The area of AAH was not seen on the initial CT scan.  Any suggestions regarding monitoring this process?

Thank you for your help.

Joe Church
Children's Hospital Los Angeles

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Charlotte Cunningham-Rundles MD PhD
David S Gottesman Professor
Department of Medicine
1425 Madison Avenue
New York City  NY 10029
Charlotte.Cunningham-Rundles at mssm.edu<mailto:Charlotte.Cunningham-Rundles at mssm.edu>

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