[CIS PIDD] [cis-pidd] 5yo PCD + SAD

[CIS-PIDD]

Dear Joe,

I agree. MMR did not cause harm in these PCD patients.

Isabelle Meyts
UZ Leuven BE




Op 21-sep.-2016 om 07:54 heeft CIS-PIDD <cis-pidd at lists.clinimmsoc.org<mailto:cis-pidd at lists.clinimmsoc.org>> het volgende geschreven:

Dear Joe

I would not withhold MMR since (a) the evidence for humoral immunodeficiency is weak and (b) MMR is usually handled well in patients with agammaglobulinaemia.

John



Professor John B. Ziegler, AM
Department of Immunology & Infectious Diseases
Sydney Children's Hospital
High St., Randwick NSW 2031
Australia
T: (02) 93821515
F: + 61 + 2 93821580
E: j.ziegler at unsw.edu.au<mailto:j.ziegler at unsw.edu.au>



From: CIS-PIDD <cis-pidd at lists.clinimmsoc.org<mailto:cis-pidd at lists.clinimmsoc.org>>
Reply-To: CIS-PIDD <cis-pidd at lyris.dundee.net<mailto:cis-pidd at lyris.dundee.net>>
Date: Wednesday, 21 September 2016 at 11:33 AM
To: CIS-PIDD <cis-pidd at lyris.dundee.net<mailto:cis-pidd at lyris.dundee.net>>
Subject: [cis-pidd] 5yo PCD + SAD

Colleagues:

I follow a 5yo boy with genetically-documented primary ciliary dyskinesia (PCD) and selective antibody deficiency (SAD).  He has chronic bronchitis and otitis media.  The infecting organisms have not been identified.  The association of PCD and humoral immunodeficiency has been reported previously (Respiratory Medicine 2014;108:931-934).

My patient has an elevated IgG (1260mg/dL) and responded well to tetanus and Hib vaccines.  However, he generated >1.3mcg/mL of antibody to only 8 of 23 serotypes tested after Pneumovax.  Because of potential community exposure and the availability of effective anti-viral therapy, I administered Varicella-Zoster vaccine.  He tolerated this well and generated excellent antibody and a vigorous VZV-specific lymphoproliferative response.

My question is should I give him MMR vaccine – live attenuated viruses and no therapy if he gets measles, mumps or rubella from the vaccine?

Joe Church
Children’s Hospital Los Angeles





---------------------------------------------------------------------
CONFIDENTIALITY NOTICE: This e-mail message, including any attachments,
is for the sole use of the intended recipient(s) and may contain confidential
or legally privileged information. Any unauthorized review, use, disclosure
or distribution is prohibited. If you are not the intended recipient, please
contact the sender by reply e-mail and destroy all copies of this original message.

---------------------------------------------------------------------

---

You are currently subscribed to cis-pidd as: j.ziegler at unsw.edu.au<mailto:j.ziegler at unsw.edu.au>.

To unsubscribe click here: http://cts.dundee.net/u?id=96396640.adcca036b6460aa865f1c3c405d26562&n=T&l=cis-pidd&o=3851582

(It may be necessary to cut and paste the above URL if the line is broken)

or send a blank email to leave-3851582-96396640.adcca036b6460aa865f1c3c405d26562 at lyris.dundee.net<mailto:leave-3851582-96396640.adcca036b6460aa865f1c3c405d26562 at lyris.dundee.net>

---

You are currently subscribed to cis-pidd as: Isabelle.Meyts at uzleuven.be<mailto:Isabelle.Meyts at uzleuven.be>.

To unsubscribe click here: http://cts.dundee.net/u?id=96396636.15f0ef7c3f65602e498cc8265c1ae62d&n=T&l=cis-pidd&o=3851878

(It may be necessary to cut and paste the above URL if the line is broken)

or send a blank email to leave-3851878-96396636.15f0ef7c3f65602e498cc8265c1ae62d at lyris.dundee.net<mailto:leave-3851878-96396636.15f0ef7c3f65602e498cc8265c1ae62d at lyris.dundee.net>

---
You are currently subscribed to cis-pidd as: pagid at list.clinimmsoc.org.
To unsubscribe click here: http://cts.dundee.net/u?id=96396833.5a9591ccd1e327fe6bc4d1543298c482&n=T&l=cis-pidd&o=3851941
or send a blank email to leave-3851941-96396833.5a9591ccd1e327fe6bc4d1543298c482 at lyris.dundee.net
-------------- next part --------------
An HTML attachment was scrubbed...
URL: <https://pairlist7.pair.net/pipermail/pagid/attachments/20160921/20f2bd3f/attachment-0001.html>