[CIS PIDD] [cis-pidd] Rituximab s.c for GLILD therapy

[CIS-PIDD]

One can use 1000mg Q2 weeks as a cycle rather than 375mg Q wk x 4 weeks
Good luck


John M. Routes, MD
Chief, Section of Allergy and Clinical Immunology
Professor of Pediatrics, Medicine, Microbiology and Molecular Genetics
Department of Pediatrics
Children's Hospital of Wisconsin
Medical College of Wisconsin
9000 W. Wisconsin Ave.
Milwaukee, WI  53226-4874

Phone: 414-266-6061
Fax: 414-266-6437
Email: jroutes at mcw.edu<mailto:jroutes at mcw.edu>

From: CLINICAL IMMUNOLOGY LISTSERV <cis-pidd at lists.clinimmsoc.org>
Reply-To: CIS-PIDD <cis-pidd at lyris.dundee.net>
Date: Thursday, October 6, 2016 at 4:56 AM
To: CIS-PIDD <cis-pidd at lyris.dundee.net>
Subject: Re: [cis-pidd] Rituximab s.c for GLILD therapy

Dear Dr Rothenfusser,
in my experience, GLILD in a 10yo boy with "cvid" (rather CID with predominant hypogamma, Bmem deficiency, and LPD) melted away during 4-6 months under a combination of one cycle of 4x375 Rituximab plus one dose of prednisone at each infusion and concomitant start of sirolimus, the latter continued over one year, now being slowly tapered. (and IgG replacement, as before).
How was your dx of glild verified? What is the underlying cvid subtype/pathomechanism, was apds excluded...?
More details per personal contact, if you wish.
Best,
Markus Seidel
Univ.-Prof. Dr. Markus G. Seidel | Pädiatrische Hämatologie-Onkologie | Med. Univ. Graz | Auenbruggerplatz 38 | 8036 GRAZ | Austria | Tel +43 316 385 80215 | Secr +43 316 385 13485 | Fax +43 316 385 13717 | sent from my mobile phone | please excuse typos

Am 06.10.2016 um 11:19 schrieb CIS-PIDD <cis-pidd at lists.clinimmsoc.org<mailto:cis-pidd at lists.clinimmsoc.org>>:
Dear colleagues,

I intend to treat an adult CVID patient with GLILD with the rituximab/Azathioprin regimen suggested by John M. Routes with four weekly infusions of 375 mg/M2 i.v. that are then repeated every 4-6 month. As the patient worries about the time off work it would be more convenient for her to get Rituximab s.c. as the 1400 mg fix-dose given within a couple of minutes instead of the infusions that take several hours.
Has anybody used the sc. version of Rituximab for GLILD/CVID and could suggest a regimen that might in effect be similar to John Routes's iv. regimen? Weekly injection of Rituximab 1400 mg do not seem to be in use for Lymphoma and just giving replacing the weekly iv. doses by the sc. Dose might be too much?

Thanks for advice!

Prof. Dr. Simon Rothenfusser
Immundefekt-Ambulanz für Erwachsene („AIDA“)
Medizinische Klinik IV
Klinikum der Ludwigs-Maximilian Universität
Pettenkoferstraße 8a, 80336 München

Tel. *49-89-4400-53568
Fax: 089/4400-53719
E-mail: Simon.rothenfusser at med.uni-muenchen.de<mailto:Simon.rothenfusser at med.uni-muenchen.de>

www.klinikum.uni-muenchen.de/Medizinische-Poliklinik-Innenstadt/de/rheumaeinheit/rheuma-ambulanz/<http://www.klinikum.uni-muenchen.de/Medizinische-Poliklinik-Innenstadt/de/rheumaeinheit/rheuma-ambulanz/>

---

You are currently subscribed to cis-pidd as: markus.seidel at medunigraz.at<mailto:markus.seidel at medunigraz.at>.

To unsubscribe click here: http://cts.dundee.net/u?id=96396792.78d82ba41fe333edaa9195bab4e19c0e&n=T&l=cis-pidd&o=3883051

(It may be necessary to cut and paste the above URL if the line is broken)

or send a blank email to leave-3883051-96396792.78d82ba41fe333edaa9195bab4e19c0e at lyris.dundee.net<mailto:leave-3883051-96396792.78d82ba41fe333edaa9195bab4e19c0e at lyris.dundee.net>

---

You are currently subscribed to cis-pidd as: jroutes at mcw.edu<mailto:jroutes at mcw.edu>.

To unsubscribe click here: http://cts.dundee.net/u?id=96396698.0f5699ec627ea78458de58d3499414e5&n=T&l=cis-pidd&o=3883099

(It may be necessary to cut and paste the above URL if the line is broken)

or send a blank email to leave-3883099-96396698.0f5699ec627ea78458de58d3499414e5 at lyris.dundee.net<mailto:leave-3883099-96396698.0f5699ec627ea78458de58d3499414e5 at lyris.dundee.net>

---
You are currently subscribed to cis-pidd as: pagid at list.clinimmsoc.org.
To unsubscribe click here: http://cts.dundee.net/u?id=96396833.5a9591ccd1e327fe6bc4d1543298c482&n=T&l=cis-pidd&o=3883602
or send a blank email to leave-3883602-96396833.5a9591ccd1e327fe6bc4d1543298c482 at lyris.dundee.net